Cancer Control

癌症控制计划：总结 癌症控制（CC）计划促进旨在降低癌症发病率的人口科学研究 在南卡罗来纳州，同时提供新的，循证的癌症控制干预措施， 适用于国家的边界之外。以两个贯穿各领域的主题-癌症差异和烟草控制-为指导， 协调委员会成员在所有领域都取得了显著进展。为了解决癌症健康差距，CC成员- 建立了一个精确的医学中心，以剖析和解决复杂的遗传，心理和社会因素， 影响癌症差异的因素，建立了增加少数患者参加临床试验的制度， 并将晚期糖基化终产物确定为非洲美洲2期试验的药理学靶点， 也会影响社会经济地位低下的癌症患者。烟草控制的进展包括鉴定新的 增加吸烟复吸风险的认知机制， 戒烟，并实施住院戒烟服务，减少再入院。 由少数民族健康国家领导人Chanita Hughes-Halbert博士和Matthew J. Carpenter博士共同领导 和癌症的差距和烟草控制，分别，该方案包括25个人口健康和物理- 来自九个系的科学家和科学家。不包括职业发展和培训赠款， 该计划的年度直接同行评审资金总额为440万美元，比上一年度增加了37.5%。 更新，160万美元来自NCI，210万美元来自其他NIH奖项，60万美元来自其他同行评审 源CC成员促进合作研究，并领导几个新的大型中心奖项和合作 赠款，包括NCI P01，NCI UG 1，NCI U 54和NIMHD U 54。通过完善的训练管道- 线，成员投资于指导，因此，六个初级教师举行同行评审的职业发展 奖在过去五年中，CC成员撰写了183篇与癌症相关的出版物，其中83% 我们与霍林斯癌症中心的成员在CC和其他研究项目合作。的特殊 该计划的研究质量反映在对癌症差异原因的变革性见解上， 发现潜在的癌症易感性的分子和行为风险因素，并评估证据- 鼓励戒烟的方法。这些已发表在顶级期刊上，例如 《柳叶刀》、《柳叶刀肿瘤学》、《新英格兰医学杂志》、《医学遗传学杂志》、《美国呼吸和重症监护医学杂志》、《美国医学会精神病学杂志》、《临床医学杂志》 Oncol和Nat Genet。CC成员在护理提供、产前护理和产后护理等领域推出了创新的试验干预措施。 干预，支持性护理，改善诊断和生存率，842人参加了干预性治疗， 2017年的研究。随着持续强大的教师招聘，新兴的独立科学家的指导， 跨学科团队的跨计划倡议的发展，CC计划是例外 有能力领导南卡罗来纳州减少癌症负担的努力。

CANCER CONTROL PROGRAM: SUMMARY The Cancer Control (CC) Program fosters population sciences research that seeks to reduce cancer morbidity and mortality in South Carolina while providing novel, evidence-based cancer control interventions that can be applied beyond the state’s borders. Guided by two cross-cutting themes, cancer disparities and tobacco control, CC members have made marked progress in all areas. To address cancer health disparities, CC members es- tablished a precision medicine center to dissect and address the complex genetic, psychological, and social fac- tors impacting cancer disparities, established systems to increase the accrual of minority patients to clinical trials, and identified advanced glycation endproducts as a pharmacological target for a phase 2 trial in African Ameri- can cancer patients of low socioeconomic status. Advances in tobacco control include identification of neu- rocognitive mechanisms that increase smoking relapse risk, development of pharmacological strategies for smoking cessation, and implementation of an inpatient stop smoking service that reduces hospital readmissions. Co-led by Chanita Hughes-Halbert, PhD and Matthew J. Carpenter, PhD, national leaders in minority health and cancer disparities and tobacco control, respectively, the program comprises 25 population health and phy- sician-scientist faculty members from nine departments. Excluding career development and training grants, the annual total direct peer-reviewed funding base for the program is $4.4M, an increase of 37.5% since the prior renewal, with $1.6M from the NCI, $2.1M from other NIH awards, and $0.6M from other peer-reviewed sources. CC members foster collaborative research and lead several new large center awards and cooperative grants, including an NCI P01, NCI UG1, NCI U54, and an NIMHD U54. Through well-established training pipe- lines, members invest in mentoring and, as a result, six junior faculty hold peer-reviewed career development awards. During the past five years, CC members authored 183 cancer-relevant publications, of which 83% were collaborative with Hollings Cancer Center members in CC and other research programs. The exceptional quality of the program’s research is reflected by transformative insights into the causes of cancer disparities, discovery of molecular and behavioral risk factors underlying cancer susceptibility, and evaluation of evidence- based approaches to encourage tobacco cessation. These have been published in top-tier journals such as Lancet, Lancet Oncol, N Engl J Med, J Med Genet, Am J Respir and Crit Care Med, JAMA Psychiatry, J Clin Oncol, and Nat Genet. CC members launched innovative trial interventions in the areas of care delivery, pre- vention, supportive care, improved diagnostics, and survivorship, with 842 individuals enrolled in interventional studies in 2017. With continued strong faculty recruitment, mentoring of emerging independent scientists, and development of transdisciplinary team-based interprogrammatic initiatives, the CC Program is exceptionally well equipped to lead efforts in reducing the cancer burden in South Carolina.