Summer Endocrine Research Training Program

摘要： 这是T35短期医学生暑期培训计划的竞争性续签申请， NIDDK资助了15年的内分泌研究。两个具体目标是：（1）提供 在基础和临床内分泌相关研究的实践培训，以结构化的指导医学生 环境; 2）提供互动的教育体验，向医学生介绍 基础，转化和临床内分泌相关研究所需的基本技能。该计划已 支持对6名二年级医学生进行内分泌研究课题（包括糖尿病）的培训， 特别关注糖尿病肾病、内分泌恶性肿瘤、垂体调节肽类激素 表达，非酒精性脂肪肝，糖尿病和肥胖的心血管并发症，激素 代谢调节和干细胞生物学。学员是从大学一年级的学生中挑选出来的。 路易斯维尔医学院（SOM）申请夏季研究学者计划（SRSP）。一个成功 已作出努力，招收代表性不足的少数民族和处境不利背景的学生。 学生审查由28名教师研究导师提交的可用项目，并输入他们的第1 - 3选择， 让学员与导师配对。学员和导师之间的面对面会议确保了“适合” 在春季学期的中间。在为期10周的夏季培训中，学生与导师一起工作， 临床或实验室环境中的研究项目，完成负责任的研究行为培训， 包括管理科学数据、捏造和伪造数据、剽窃、出版行为和 负责任的作者，指导，管理和利益冲突。与人类一起工作的受训者 受试者完成人类受试者和IRB培训。在导师实验室使用脊椎动物的受训者 完成并通过IACUC培训课程。所有学员参加每周一次的夏季内分泌研究 介绍内分泌学临床/转化研究的培训班。一个重要的组成部分，以及- T35教师的导师们将提高再现性的方法的讨论整合到这门课中。的 课程的高潮是每个学员向同行和导师介绍他/她的研究项目。受训人员还 在SOM范围内为期一周的研究庆祝活动中以海报的形式展示他们的研究成果！路易斯维尔 海报比赛的获奖者有机会参加全国学生研究论坛， 春天之后。学员可以选择继续研究，作为研究（卓越）轨道的一部分 丰富计划，提供整个医学院课程的研究经验，包括在 第三年和第四年，朝着培养临床研究人员的目标。学员发表了 在同行评审的期刊和/或在国家或国际论坛上介绍他们的研究，许多人 在他们的医学院毕业证书上得到了“荣誉”。跟踪受训人员的职业成果， 这个T35计划对作为医生科学家的职业生涯的影响。

Abstract: This is a competing renewal application for a T35 short term medical student summer training program in endocrine research that has been funded by NIDDK for 15 years. The 2 Specific Aims are 1) To provide hands-on training in basic and clinical Endocrine-related research to medical students in a structured mentored environment; 2) To provide an interactive, educational experience that introduces medical students the fundamental skills necessary for basic, translational, and clinical Endocrine-related research. The program has supported the training of 6 second year medical students in endocrine research topics including diabetes – with a particular focus on diabetic kidney disease, endocrine malignancies, pituitary regulation of peptide hormone expression, non-alcoholic fatty liver disease, cardiovascular complications of diabetes and obesity, hormonal regulation of metabolism, and stem cell biology. Trainees are selected from the first year class at University of Louisville School of Medicine (SOM) applying for the summer research scholar program (SRSP). A successful effort has been made to recruit students from underrepresented minorities and disadvantaged backgrounds. Students review the available projects submitted by 28 faculty research mentors and enter their 1st-3rd choices, allowing matching of trainees with mentors. In-person meetings between trainees and mentors assures the ‘fit’ in the middle of the Spring semester. During the 10 week summer training, students work with mentors on research projects in clinical or laboratory settings, complete training in the Responsible Conduct of Research, including managing scientific data, fabrication and falsification of data, plagiarism, publication practices and responsible authorship, mentorship, stewardship, and conflict of interest. Trainees working with human subjects complete human subject and IRB training. Trainees who use vertebrate animals in mentors’ labs complete and pass IACUC training courses. All trainees attend a weekly Summer Endocrine Research Training Class to introduce clinical/translational research in endocrinology. An essential component well- integrated into this class by T35 faculty mentors is discussion of methods for enhancing reproducibility. The Class culminates with each trainee presenting his/her research project to peers and mentors. Trainees also present their research results as posters at a SOM-wide, week-long celebration of Research!Louisville. Winners from the poster contest have the opportunity to attend the National Student Research Forum the following Spring. Trainees may choose to continue research as part of the Distinction in Research (DIR) track enrichment program that provides research experiences throughout the medical school curriculum, including in the third and fourth years, toward the goal of developing clinician-researchers. Student trainees have published in peer reviewed journals and/or presented their research in national or international forums and many have received the DIR notation on their medical school diplomas. Trainee career outcomes are tracked to assess the impact of this T35 program on careers as physician-scientists.