Training Grant in Clinical Pharmacology

摘要 这项提案代表了对NIH赞助的临床药理学继续提供资金的请求 梅奥诊所的T32团契培训计划。该计划的基础是在以下方面进行强有力的培训 应用于人类-药物相互作用的最先进的生物医学研究。梅奥临床药理学 培训经验包括一门课程，系统地让学员了解 作为临床药理学基础的科学。然而，在正规课程之外， 在支持性的指导环境中，培训是一种出色的个人研究体验。 临床药理学是一门致力于研究药物与药物相互作用的“桥梁学科” 生物系统。然而，在正在进行的生物医学革命的背景下， 科学，一场有望改变医疗实践的革命，临床药理学在于 分子药理学、基因组学和其他“组学”学科的融合。此外, 生物信息学、系统药理学和新的计算方法也越来越多地 成为临床药理学的关键组成部分--最终目标是真正的“个体化” 合理的药物治疗。具体地说，临床药理学旨在加强我们对 药物反应的分子基础及其在翻译界面上的应用 可以根据潜在的疾病过程和每种疾病的独特特征量身定做药物治疗 个别病人。我们利用巨大进步所代表的机会的能力 在生物医学科学中正在发生，以实现“最终目标”将需要我们培养一种新的 《系统临床药理学》中临床药理学家的生成。大型的、综合的、 像梅奥诊所这样的综合性学术医疗中心非常适合培养新一代 临床药剂师。梅奥之所以能够做到这一点，是因为它有着悠久的支持和表演历史 杰出的基础和临床医学研究以及两者的结合。梅奥也有悠久的传统 对临床药理学学科的持续贡献以及数十年的经验 成功招聘和培训内科科学家和实验室翻译科学家 临床药理学。在下一个资助周期，梅奥临床药理学奖学金培训 计划将继续强调以实验室为基础的强有力的研究培训，在支持性的指导下 环境与强大和不断发展的Curriuculum相结合，并有系统地接触到 临床科学，强调生物医学科学的快速发展性质-所有这些都是针对 培养每一位参加该项目的研究员成为未来临床领导者的目标 药理学。

ABSTRACT This proposal represents a request for continued funding of the NIH-sponsored Clinical Pharmacology T32 Fellowship Training Program at the Mayo Clinic. The foundation for this program is strong training in state-of-the-art biomedical research as applied to human-drug interactions. The Mayo Clinical Pharmacology training experience includes a curriculum that systematically exposes Trainees to critical aspects of the science that underlies Clinical Pharmacology. However, beyond the formal curriculum, at the heart of the training is an outstanding individual research experience within a supportive mentoring environment. Clinical Pharmacology is a “bridge discipline” devoted to studies of the interaction between drugs and biological systems. However, within the context of the ongoing “revolution” that is occurring in biomedical science, a revolution that promises to transform medical practice, Clinical Pharmacology lies at the confluence of molecular pharmacology, genomics and other “omics” disciplines. In addition, increasingly, bioinformatics, systems pharmacology and novel computational methods are also becoming critical compotents of Clinical Pharmacology—with an ultimate goal of truly “individualized” and rational drug therapy. Specifically, Clinical Pharmacology seeks to enhance our understanding of the molecular basis for drug response and the application of that information at the translational interface to make it possible to tailor drug therapy to both the underlying disease process and the unique characteristics of each individual patient. Our ability to take advantage of the opportunity represented by the dramatic advances that are occurring in biomedical science to achieve that “ultimate goal” will require that we train a new generation of Clinical Pharmacologists in “Systems Clinical Pharmacology”. Large, comprehensive, integrated academic medical centers like the Mayo Clinic are ideally positioned to train this new generation of Clinical Pharmacologists. Mayo is able to do that because of its long history of supporting and performing outstanding basic and clinical medical research and of integrating the two. Mayo also has a long tradition of contining contributions to the discipline of Clinical Pharmacology as well as decades of experience in successfully recruiting and training both physician scientists and laboratory-based translational scientists in Clinical Pharmacology. During the next funding cycle, the Mayo Clinical Pharmacology Fellowship Training Program will continue to emphasize strong laboratory-based research training in a supportive mentored environment joined with a strong and evolving curriuculum and systematic exposure to novel developments in clinical science, with an emphasis on the rapidly advancing nature of biomedical science—all directed toward the goal of preparing each Fellow enrolled in the Program to become a future leader in Clinical Pharmacology.