Fluorescent probes for super-resolution imaging of the amyloid architecture

该项目的目标是开发能够对淀粉样蛋白结构进行分子水平成像的化学工具。获得诺贝尔奖的超分辨率显微镜提供了纳米级成像能力，但令人惊讶的是，还没有实质性的努力来设计与这种尖端技术兼容的荧光传感器。在这个项目中，将开发新的荧光超分辨率传感器，使淀粉样蛋白组装的纳米级可视化成为可能。这些化学和生化研究将为开发超分辨率成像应用的荧光传感器建立合理的设计策略，并显著促进我们对功能和有毒蛋白质组装的基本差异的理解。

The goal of this project is to develop chemical tools that enable molecular-level imaging of the amyloid structure. The Nobel Prize-winning super-resolution microscopy provides nanoscale imaging capabilities, but surprisingly there have been no substantive efforts to design fluorescent sensors that are compatible with this cutting-edge technology. In this project, new fluorescent super-resolution sensors will be developed that enable nanoscale visualisation of amyloid assemblies. These chemical and biochemical studies will establish rational design strategies to develop fluorescent sensors for super-resolution imaging applications and significantly advance our understanding of fundamental differences functional and toxic protein assemblies.