Vanderbilt Hypertension and Blood Pressure Regulation Program

摘要 这是一个新的项目，旨在培养高血压和血液领域的下一代科学家 压力调节。这些情况代表着巨大的医疗保健问题。新的美国心脏 协会和美国心脏病学会的指南现在对近50%的成年人进行分类 人口都是高血压患者。自主神经功能障碍，表现为晕厥、晕厥前和 姿势不容忍，随着年龄的增长变得越来越普遍，严重致残。尽管 尽管这些疾病具有共性，但其确切病因仍未明确。此外，他们经常 与其他心血管和代谢紊乱相关并具有相同的潜在机制。它是 因此，我们必须培养和发展优秀的科学家，以追求这些相关领域的 调查。我们建议最终包括4名博士后研究员和2名博士后研究生 在范德比尔特高血压和血压调节(VHBPR)计划中。这些实习生将成为 涉及研究的三个相关方面。这与了解高血压的发病机制有关 并终止器官损伤及炎症和免疫激活的作用。VHBPR的成员领导了 定义高血压的免疫激活机制和相关领域的领域，这已经 演变成对发生的血管、肾脏和大脑功能障碍和损害的新理解 以及相关的心血管疾病。参与这些计划的实习生将熟悉 这是一个新兴的免疫学领域，因为它与高血压和心血管疾病有关。这个 第二个重要的调查领域由我们的范德比尔特自主神经功能障碍中心进行。这 该中心进行包括实验室、动物和临床研究在内的转化性研究。第三个主要领域 研究的内容涉及高血压和药物反应的生物信息学。这些研究在很大程度上 由BioVu数据库(Vanderbilt DNA数据库)推动，该数据库包含300,000名患者的DNA 和合成衍生品(与BioVu链接的未识别的医疗记录)，并由我们的 基因医学部和个体化医学中心。我们的实习生将有机会 启动对耐药高血压的研究，因为超过15,000名BioVU患者患有 记录在案的耐药高血压将在2018年前完成基因组询问， 包括大量的非裔美国人主体。除了这些实验室研究 VHBPR方案包括研讨会、说教讲座和专业课作业 致力于职业发展、领导力、负责任的研究行为和工作与生活的平衡。在……里面 除了这一核心课程外，专业领域的学员还将参加量身定做的课程和 与其具体调查领域有关的讲习班。其最终目标是培养成功的科学家。 这将成功地争夺未来的资金，以及谁可以追求成功的学术生涯。

ABSTRACT This is a new program to train the next generation of scientists in the fields of hypertension and blood pressure regulation. These conditions represent enormous health care problems. The new American Heart Association and American College of Cardiology Guidelines now classify almost 50% of the adult population as being hypertensive. Autonomic dysfunction, manifested by syncope, presyncope and postural intolerance, becomes increasingly common with age and is terribly disabling. Despite the commonality of these disorders, their precise etiology remains poorly defined. Moreover, they often associated with and share underlying mechanisms with other cardiovascular and metabolic disorders. It is therefore mandatory that we train and develop outstanding scientists to pursue these related areas of investigation. We propose to ultimately include 4 post-doctoral fellows and 2 predoctoral graduate students in Vanderbilt Hypertension and Blood Pressure Regulation (VHBPR) program. These trainees will be involved in three related facets of research. One has to do with understanding mechanisms of hypertension and end organ damage and the role inflammation and immune activation. Members of the VHBPR have led the field in defining mechanisms of immune activation in hypertension and related fields and this has evolved into a new understanding of the vascular, renal and cerebral dysfunction and damage that occurs in this and associated cardiovascular illnesses. Trainees involved in these programs will become familiar with an emerging area of immunology as it pertains to hypertension and cardiovascular diseases. The second important area of investigation is conducted by our Vanderbilt Autonomic Dysfunction Center. This center performs translational research involving laboratory, animal and clinical research. A third major area of investigation relates to bioinformatics of hypertension and drug responses. These studies are greatly facilitated by the BioVu database (the Vanderbilt DNA database) that contains DNA for >300,000 patients and the Synthetic derivative (de-identified medical records linked to BioVu) and are facilitated by our Division of Genetic Medicine and Center for Personalized Medicine. Our trainees will have the opportunity to initiate studies on medication-resistant hypertension, as more than 15,000 BioVU subjects with documented medication-resistant hypertension will have genome interrogation completed by 2018, including a large number of African American subjects. In addition to these laboratory research experiences, the VHBPR program includes seminars, didactic lectures and specialized course work devoted to career development, leadership, responsible conduct of research and work life balance. In addition to this core curriculum, trainees in specialized areas will participate in tailored coursework and workshops related to their specific areas of investigation. The ultimate goal is to train successful scientists that will successfully compete for future funding and who can pursue successful academic careers.