Exposure Assessment Core

总结/摘要（暴露评估核心） 暴露评估（EA）核心为推进密歇根生命阶段中心提供关键支持 环境暴露和疾病（M-LEEaD）使命通过广泛的暴露评估 为M-LEEaD科学家提供服务。选管会在试点项目中进行风险分析，促进设计， 执行、分析和描述环境暴露，并扩大使用和 曝光测量的能力。EA核心有助于确保风险评估和 中心成员生成和使用的分析数据在科学上是合理的，质量有保证， 最先进的知识和专业技能。EA核心还进一步推动了M的翻译愿景和举措， 通过参与旨在向政策和非专业公众提供信息的外联和翻译倡议，实现LEEaD。的 具体目标是：（1）提供分析服务，以测量和描述环境暴露， 调查疾病与疾病之间联系的研究;（2）提供咨询、转诊和其他服务， 支持风险评估活动;（3）协调和利用与以下方面有关的风险评估活动： 暴露评估，特别是生物监测;（4）提高暴露的性能和能力 （5）向中心研究者传播暴露评估相关信息， 向公众和其他利益攸关方进行宣传。EA核心旨在使用创新的方法，包括使用 新的和增强的采样和分析方法。核心管理和活动鼓励 在开发试点项目和提案以及执行研究中使用EA Core。EA核心 提供免费咨询，获得广泛的服务菜单，以及“一站式”购物方式， 利用暴露测量、提高研究生产力和促进跨学科工作的目标 为M-LEEaD成员和其他从事环境健康科学研究的人提供服务。访问EA核心 可供M-LEEaD成员，密歇根大学科学家和其他研究人员使用。成本匹配 M-LEEaD会员可获得分析服务折扣费，具体取决于分析物、矩阵 和服务EA核心资金在必要和可行的情况下帮助支持方法制定、统计分析， 暴露建模和数据解释，即，这些项目不向中心会员收费。EA核心 基金还帮助扩大试点项目，启动和支持方法开发和探索工作， 促进合作和支持实验室参与实验室间的相互比较， 质量保证和其他目的。支持接触评估的方法开发活动 中心成员的活动包括推进生物标志物测量，包括使用先进的 GC/MS-MS方法，使用存档的干血点增强化学检测和验证 样本、组合基因组/生物标志物优化;以及暴露绘图。

SUMMARY/ABSTRACT (Exposure Assessment Core) The Exposure Assessment (EA) Core provides critical support to advance the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) mission through a broad range of exposure assessment services for M-LEEaD scientists. The EAC conducts exposure analyses in pilot projects, facilitates the design, implementation, analysis and characterization of environmental exposures, and expands the use and capabilities of exposure measurements. The EA Core helps to ensure that exposure assessments and analytical data generated and used by Center members are scientifically sound, quality-assured, and reflect state-of-the-art knowledge and expertise. The EA Core also furthers the translational vision and initiatives of M- LEEaD by participating in outreach and translational initiatives aimed at informing policy and the lay public. The specific aims are to: (1) provide analytical services to measure and characterize environmental exposures for research investigating exposure-disease links; (2) provide consultations, referrals and other services that support exposure assessment activities; (3) coordinate and leverage exposure assessment activities related to exposure assessment, particularly biomonitoring; (4) advance the performance and capability of exposure measurements; and (5) disseminate exposure assessment related information to Center investigators and outreach to the public and other stakeholders. The EA Core aims to use innovative methods, including the use of novel and enhanced sampling and analytical methods. Core management and activities encourage utilization of the EA Core in developing pilot projects and proposals and in executing research. The EA Core provides free consultations, access to a broad menu of services, and “one-stop” shopping approach with the goal of utilizing exposure measurements, enhancing research productivity, and promoting interdisciplinary work for M-LEEaD members and others engaged in environmental health sciences research. Access to the EA Core is available to M-LEEaD members, University of Michigan scientists, and other investigators. Cost-matching and discounted fees for analytical services are available to M-LEEaD members, depending on analyte, matrix and service. EA Core funds help support, as needed and feasible, methods development, statistical analyses, exposure modeling and data interpretations, i.e., these items are not charged to Center members. EA Core funds also help augment pilot projects, initiate and support method development and exploratory work, and promote participation with collaborating and supporting laboratories for inter-laboratory inter-comparisons for quality assurance and other purposes. Method development activities supporting exposure assessment activities of Center members include advancing biomarker measurements, including the use of advanced GC/MS-MS approaches, enhanced chemical detection and validation using archived dried blood spots samples, combined genome/biomarker optimization; and exposure mapping.