Core A: Administrative Core

管理核心（核心A）：项目概要/摘要 行政核心负责战略规划、全面管理和协调 计划项目（P01）“埃博拉病毒免疫反应失调的分子机制”。它 提供治理、财务监督和运营管理职能，以促进 总体研究计划，从而使该计划能够履行其使命，以表征转录， 埃博拉病毒感染后的转录后和翻译后机制，导致 免疫反应失调行政核心将提供一个组织和方案 通过科学互动促进研究生产力和协同作用。核心将提供 监督确定优先事项，包括涉及持续评估研究的决策过程 由私家侦探和顾问委员会核心人员将确保该计划包括生物统计学的严格性， 符合涉及使用脊椎动物、选择性制剂和BSL-4设施的问题，并将 确保为未来的产品开发活动提供监管专业知识。管理活动 在外部咨询委员会的建议下，与核心领导层密切合作开展工作。 最大限度地利用电子邮件、电话会议和视频会议，以促进 德克萨斯大学医学分支，P01的牵头机构和参与机构。

ADMINISTRATIVE CORE (Core A): PROJECT SUMMARY/ABSTRACT The Administrative Core is responsible for the strategic planning, overall management, and coordination of the Program Project (P01) “Molecular Mechanisms of the Dysregulated Immune Response to Ebola Virus”. It provides governance, financial oversight, and operational management functions to facilitate the execution of the overall research plan, thereby enabling the Program to fulfill its mission to characterize the transcriptional, posttranscriptional, and posttranslational mechanisms following Ebola virus infection that lead to the dysregulated immune response. The Administrative Core will provide an organizational and programmatic structure to promote research productivity and synergy through scientific interactions. The Core will provide oversight in setting priorities, including decision-making processes involving the continual evaluation of research by the PIs and an advisory board. Core personnel will ensure that the Program includes biostatistical rigor and is compliant with issues involving the use of vertebrate animals, select agents, and BSL-4 facilities, and will ensure that regulatory expertise is available for future product development activities. Management activities are carried out with the advice of the External Advisory Committee in close collaboration with Core leadership. Emails, teleconferencing, and videoconferencing are maximally utilized to facilitate communication between the University of Texas Medical Branch, the lead institution for the P01, and participating institutions.