Quantitative and Computational Biology Graduate Program

抽象的。请求为延长综合多学科培训方案提供支助 基因组学博士前实习生，目标是为未来的科学家提供定量和 成功的生物学研究所必需的计算工具。基因组训练计划 支持普林斯顿大学研究生项目的定量和计算 生物学(QCB)和其他合作部门，包括分子生物学、计算机科学、 化学、化学和生物工程、物理、生态学和进化生物学 由刘易斯-西格勒整合基因组研究所管理。基因组学实习生能够 他们与七个系的24个附属学院中的任何一个进行实验室轮换和论文研究，由 对数量生物学和计算生物学的共同兴趣，涉及广泛的研究领域。 在拟议的资助期间，我们每年申请10个博士前职位(我们目前的水平)； 受训人员通常被任命为培训补助金，总共为期两年。受训者做实验 和计算研究：在各种模式和哺乳动物中进行实验功能基因组学 系统；计算项目，从大规模基因组数据集成、分析和 人类起源和进化的可视化；单细胞基因组学和其他基因组学技术 开发；以及从微生物新陈代谢到生物物理学的系统生物学项目 转录调控。学员有个性化、高效的培训计划，培训计划的平均跨度 对于那些在过去十年里获得博士学位的人来说，是4.9年。正规培训包括以下课程 基因组学和基因组分析，一个系列研讨会，一个期刊俱乐部/演讲课程，负责 进行适合实验和计算研究的研究培训，以及其他 以研究所为中心的多学科活动。实习生有机会在一个 普林斯顿大学面向本科生的创新多学科入门课程。最后，受训人员和 符合条件的教职员工参加一系列活动，旨在招募和教授符合以下条件的个人 代表人数不足的少数群体的成员。

Abstract. Support is requested for the renewal of an integrated, multidisciplinary training program for pre-doctoral trainees in genomics, with the goal of providing future scientists with the quantitative and computational tools necessary for successful biological research. The genome-training program supports students in Princeton University’s Graduate Program in Quantitative and Computational Biology (QCB) and other partner departments, including Molecular Biology, Computer Science, Chemistry, Chemical and Biological Engineering, Physics, and Ecology and Evolutionary Biology and is administered by the Lewis-Sigler Institute for Integrative Genomics. Genomics trainees are able to do their lab rotations and thesis research with any of 24 affiliated faculty in seven departments united by common interests in quantitative and computational biology, across a wide range of research areas. We request 10 pre-doctoral positions (our current level) each year during the proposed grant period; trainees typically are appointed to the training grant for a total of two years. Trainees do experimental and computational research in: experimental functional genomics in a variety of model and mammalian systems; computational projects ranging from large-scale genomics data integration, analysis, and visualization to human origins and evolution; single-cell genomics and other genomics technology development; and systems biology projects ranging from microbial metabolism to the biophysics of transcriptional regulation. Trainees have individualized, efficient training plans, which span on average 4.9 years, for those who received their Ph.D. in the last ten years. Formal training includes courses in genomics and genomic analysis, a seminar series, a journal club / presentation course, responsible conduct in research training appropriate for both experimental and computational research, and other multidisciplinary activities centered in the Institute. Trainees have the opportunity to teach in an innovative multidisciplinary introductory program for undergraduates at Princeton. Finally, trainees and eligible faculty participate in a number of activities designed to recruit and teach individuals who are members of under-represented minority groups.