Adult Changes in Thought (ACT) Research Program Core C: Life Course Core

核心C：生活课程核心 项目摘要 在思想（ACT）U19研究计划的首要目标是使用一个生命历程的成人变化 研究影响认知和阿尔茨海默病的可变因素和其他因素的方法， 相关的痴呆症，包括更好地了解潜在的机制。Life Course Core提供 数据和理论支持这一目标。核心利用现有的凯撒永久华盛顿 （KPWA）电子数据文件和医疗记录，现有的ACT数据，新的调查工具，以及 公共领域。通过有效地利用ACT作为长期纵向队列的广泛资源， 在医疗保健提供系统中，生命历程核心将支持科学探究，以提高我们的 对衰老的理解，特别是大脑衰老、痴呆和阿尔茨海默病。跨学科 核心团队拥有生命周期流行病学、建筑环境、神经科学和卫生政策方面的专业知识 和计量经济学将在所有项目和核心活动中支持生命过程框架。生命历程 Core的具体目标是：目标1）聚合来自不同来源的数据（包括管理 调查表和与外部数据来源的联系），以描述整个生命过程中的社会经济状况; 目的2）验证大脑发育和功能的特定关键时期决定时间的假设 个人和地区社会经济地位指标与晚年认知轨迹的相关性; 和目标3）协助项目从新收集的数据中确定相关的生命过程参数， 现有变量，并与核心合作，将最具影响力的变量整合到其分析中， 了解痴呆症的强大认知功能的频谱。整合新的社会和健康数据， 生命过程将允许该核心与其他核心一起工作，以支持三个项目的目标， 更广泛的科学努力。我们将与临床核心和数据密切合作， 分析核心，分别收集和共享数据。Life Course Core在U19中发挥着核心作用 通过提供主题统一，将改变ACT U19计划科学的未来价值。

CORE C: LIFE COURSE CORE PROJECT SUMMARY The Adult Changes in Thought (ACT) U19 Research Program’s overarching goal is to use a life course approach to investigate modifiable and other factors that influence cognition and Alzheimer’s disease and related dementia, including better understanding of underlying mechanisms. The Life Course Core provides data and theoretical support for this goal. The Core leverages existing Kaiser Permanente Washington (KPWA) electronic data files and medical records, existing ACT data, new survey instruments, and data in the public domain. By efficiently building on the extensive resources of ACT as a long-standing longitudinal cohort set in a health care delivery system, the Life Course Core will support scientific inquiry to enhance our understanding of aging, especially brain aging and dementia and Alzheimer’s disease. The interdisciplinary Core team with expertise in life course epidemiology, the built environment, neuroscience, and health policy and econometrics will support the life course framework in all Projects and Core activities. The Life Course Core’s Specific Aims are: Aim 1) To aggregate data from disparate sources (including administration of a questionnaire and linkage to external data sources) to characterize socioeconomic status over the life course; Aim 2) To test the hypothesis that specific crucial times in brain development and function determine the timing of the relevance of individual and area level socioeconomic status indicators to cognitive trajectories in late life; and Aim 3) To assist the Projects in identifying relevant life course parameters from newly collected and existing variables and partner with Cores to integrate the most influential variables into their analyses to understand the spectrum of robust cognitive function to dementia. Integrating new social and health data over the life course will allow this Core to work with other cores to support aims across the three Projects and broader scientific endeavors. We will work particularly closely with the Clinical Core and the Data and Analysis Core to collect and share data, respectively. The Life Course Core serves a central role in the U19 by providing thematic unification that will transform the future value of ACT U19 Program science.