Computerized tests of cognitive decline in presymptomatic Alzheimer’s disease

抽象的。拉美裔美国人是美国人数最多、增长最快的少数族裔，而且， 几十年来，阿尔茨海默病(AD)发病率的相对增幅将是 少数民族。然而，说西班牙语的拉美裔在很大程度上被排除在临床之外。 试验和研究研究的原因有几个：(1)只有5.5%的美国神经心理学家 足够流利，能够用西班牙语进行认知测试；(2)现有西班牙语 认知测试对年长的拉美裔美国人缺乏足够的常模，(3)许多拉美裔美国人生活在 在农村或难以到达的地方，这使得考试管理具有挑战性。在这里，我们建议 创建西班牙语版本的加州认知评估组合(CCAB)并收集 来自256名讲西班牙语的年长拉美裔美国人的标准数据，他们在家中进行了远程医疗测试。 CCAB-西班牙语将显著增强美国拉美裔美国人对 几个原因：(1)自动化和计算机化的考试交付和计分手段考官 西班牙语流利程度有限的人可以进行CCAB-西班牙语测试，随叫随到的口译员 需要；(2)全国远程医疗管理覆盖到人工服务不足的人群 测试；以及(3)一名考官可以远程测试多个科目同时进行 经济困难人群认知经济可行性的临床评估 人口。该副刊将进一步增强长期的科学性和商业性 CCAB的影响，并为讲西班牙语的老年美国居民提供更好的机会 认知测试。

Abstract. Hispanic Americans are the largest and fastest growing US minority and, over coming decades, will show the largest relative increase in Alzheimer’s disease (AD) incidence of any ethnic group. However, Spanish-speaking Hispanics have been largely excluded from clinical trials and research studies for several reasons: (1) Only 5.5% of US neuropsychologists have sufficient fluency to administer cognitive tests in Spanish; (2) Existing Spanish-language cognitive tests lack adequate norms for older Hispanic Americans, and (3) many Hispanics live in rural or hard-to-reach locations that make test administration challenging. Here, we propose to create a Spanish version of the California Cognitive Assessment Battery (CCAB) and gather normative data from 256 older Spanish-speaking Hispanics, telemedically tested in their homes. CCAB-Spanish will significantly enhance access to cognitive testing for US Hispanics for several reasons: (1) Automated and computerized test delivery and scoring means examiners with limited Spanish fluency can administer CCAB-Spanish tests, with on-call interpreters as needed; (2) Nationwide telemedical administration reaches populations underserved by manual testing; and (3) A single examiner can remotely test multiple subjects concurrently making clinical assessments of cognition economically feasible in economically disadvantaged populations. The supplement will further enhance the long-term scientific and commercial impact of the CCAB, and provide older Spanish-speaking US residents with improved access to cognitive testing.