Cancer Prevention and Control Program

项目总结/摘要 悉尼金梅尔综合癌症中心（SKCCC）癌症预防和控制的目标 该计划旨在提高对癌症危险因素的认识，改善癌症检测和改善 癌症患者的治疗结果，以减少人群中的癌症负担。为了实现这一目标，该计划 是围绕三个具体目标组织在整个癌症控制连续体和使用人口，翻译 和基础癌症预防科学方法：1）发现癌症风险因素，并开发和测试 一级预防战略，以减轻其在集水区及以外地区的影响; 2）评估 * 在临床和公共卫生领域采用基因组和其他工具，以便能够早期发现癌症， 他们的前体在人群中;和3）制定和测试干预战略，以拦截癌前或 减轻癌症幸存者的后遗症。通过与社区外展和参与联络，我们 确定研究领域的优先次序，并在我们的服务范围内外传播研究结果。该计划的 一系列研究直接解决了SKCCC集水区的主要癌症问题， 其他地方特别强调的是癌症负担的种族和其他差异，以及其他国家的癌症。 主要集水区人口，特别是艾滋病毒感染者。由Alison Klein博士领导;伊丽莎白广场， 科学博士;和理查德罗登博士该计划由41名正式成员组成，其中33人经过同行评审 资金，以及14个准成员。该计划有成员与任命在16个 学校和三所学校。与癌症直接相关的同行评审资金总额为1290万美元，其中690万美元用于治疗癌症。 美国国家癌症研究所（NCI）计划出版物总数为930份，其中183份 (19.7%）是项目内的，314（33.8%）是项目间的。其中，654篇（70.3%） 是多机构的合作。18.3%发表在影响因子≥10的期刊上，5.7%有影响力 因子≥25。该计划导致了实践的改变，范式的转变和政策的改变研究，包括 发现牙周病和癌症之间的联系;测试基于血液的早期检测工具， DETECT-A，在10，000名无癌妇女中;开发和测试治疗性HPV疫苗;以及创建和 评价多参数检测在胰腺囊肿治疗中的应用。我们发现了 健康的社会决定因素，包括经济毒性，对癌症幸存者的影响，并进行了干预 研究生活方式因素，如肥胖和吸烟，导致健康状况不佳和 癌症存活率这些努力反映了我们的研究使命，即为基于人群的癌症预防提供信息 在地方、州、国家和国际各级进行监督和控制。项目负责人促进和组织内部 和跨方案的研究合作，以使适当和有效的翻译有前途的， 新的癌症预防和控制措施，并从多项目赠款中获得资金，如 胃肠道和宫颈癌孢子。

PROJECT SUMMARY/ABSTRACT The goal of the Sidney Kimmel Comprehensive Cancer Center (SKCCC) Cancer Prevention and Control Program is to improve the understanding of cancer risk factors, improve cancer detection and improve outcomes in cancer patients to reduce cancer burden in the population. To accomplish this goal, the Program is organized around three specific aims across the cancer control continuum and uses population, translational and basic cancer prevention sciences approaches: 1) to discover cancer risk factors and to develop and test primary prevention strategies to mitigate their impact in the catchment area and beyond; 2) to evaluate the clinical and public health implementation of genomic and other tools to enable early detection of cancers and their precursors in populations; and 3) to develop and test intervention strategies to intercept precancer or mitigate the sequelae of cancer in survivors. By liaising with Community Outreach and Engagement, we prioritize research areas and disseminate findings throughout our catchment area and beyond. The Program's portfolio of research directly addresses the major cancer problems in the SKCCC catchment area and elsewhere. Special emphasis is placed on racial and other disparities in cancer burden, and cancers in other key catchment area populations, particularly those living with HIV. Led by Alison Klein, Ph.D.; Elizabeth Platz, Sc.D.; and Richard Roden, Ph.D., the Program consists of 41 Full Members, 33 of whom have peer-reviewed funding, and an additional 14 Associate Members. The Program has Members with appointments in 16 departments and three schools. Total direct cancer-relevant, peer-reviewed funding is $12.9 million, with $6.9 million from the National Cancer Institute (NCI). The total number of Program publications is 930, of which 183 (19.7%) are Intra-Programmatic and 314 (33.8%) are Inter-Programmatic. Of these publications, 654 (70.3%) are multi-institutional collaborations. 18.3% are in journals with an impact factor ≥10, and 5.7% have an impact factor ≥25. The Program has led to practice-changing, paradigm-shifting and policy-altering research, including discovering links between periodontal disease and cancer; testing a blood-based early detection tool, DETECT-A, in 10,000 cancer-free women; developing and testing therapeutic HPV vaccines; and creating and evaluating the use of a multiparameter test for management of pancreatic cysts. We uncovered the impact of social determinants of health, including financial toxicity, on cancer survivors and conducted interventional studies for lifestyle factors, such as obesity and smoking, that contribute to poor health and disparities in cancer survivorship. These efforts reflect our research mission to inform population-based cancer prevention and control at the local, state, national and international levels. Program Leaders promote and organize Intra- and Inter-Programmatic research collaborations to enable appropriate and efficient translation of promising, novel cancer prevention and control measures, and to secure funding from multiproject grants, such as the Gastrointestinal and Cervical Cancer SPOREs.