Training Grant in Gastroenterology

项目摘要/摘要 此申请要求加州大学圣地亚哥分校(UCSD)额外提供五年的培训 胃肠病学助学金继续完成为博士后和博士后研究员就业做准备的目标 作为学术界的独立研究人员，进行前沿的基础和/或翻译 胃肠道(GI)疾病相关研究。拟议的培训基于两项原则：(1) 基础研究推动了消化系统疾病诊断和治疗的进步 发现并及时将其转换到床边；(2)大数据(RNA SEQ，‘组学’)提供了 丰富的数据使这种从模型生物体研究到患者的转换成为可能，并且需要严格的 计算工具、系统生物学和生物统计学方面的培训。基于这些原则，UCSD GI T32计划设计了全面而又个性化的培训课程，以(A)实现 在先进系统和方法方面的卓越研究，(B)提供基础知识，跟上步伐 并开发翻译见解，以及(C)通过 充满活力的跨学科培训。通过这些活动，GI T32计划旨在加快 发现并推进对消化系统疾病的精准管理，这是直接的 与NIDDK减轻这些疾病负担的目标一致。本培训计划利用 继续扩大加州大学圣迭戈分校医学院及其合作机构的生物医学研究 确定具有GI相关研究专业知识、富有成效的研究计划、原则性的教师导师 医学部、家庭医学部、家庭医学部、 细胞和分子医学、儿科学、病理学、药理学、外科和药剂学 科学。培训计划使受训者和教职员工接触到系统的多样性， 用于研究复杂生物学和翻译的方法和技术 一系列胃肠道疾病的方面，包括炎症性肠病、功能性胃肠道疾病和 运动、肠道传染病、肠道微生物群、胰腺和肝胆疾病、营养和 肥胖症和消化道恶性肿瘤。在过去的十年里，这方面的博士后和博士后学员 计划进入了富有成效的研究生涯，成功率分别为100%和~90%，如 研究科学家和教职员工。UCSD GI T32计划执行委员会，由计划组成 主任、副主任和内部咨询委员会，负责挑选和评估受训人员和 并监督该计划的进展情况。加州大学圣迭戈分校GI T32外部咨询委员会 审查计划统计数据和衡量标准，以确定培训活动的优势和劣势； 实习生和教职员工。在这些活动和加州大学圣迭戈分校医学院的支持下，该计划将 继续作为UCSD以GI为重点的基础和翻译研究和培训的纽带发挥作用。

PROJECT SUMMARY/ABSTRACT This application requests five additional years for the University of California, San Diego (UCSD) Training Grant in Gastroenterology to continue to fulfill its goal of preparing pre- and post-doctoral fellows for careers as independent investigators in academia, conducting cutting-edge basic and/or translational gastrointestinal (GI) disease-related research. The proposed training is based on two principles: (i) Advancements in diagnosis and treatment of digestive disorders are propelled by basic research discoveries and their timely translation to the bed side; (ii) Big data (RNA seq, 'omics') has provided a wealth of data to enable such translation from model organism research to patients and requires rigorous training in computational tools, systems biology and biostatistics. Based on these principles, the UCSD GI T32 program has designed a comprehensive, and yet individualized training curriculum to (a) achieve research excellence in advanced systems and approaches, (b) provide foundation knowledge, keep pace with advancements and develop translational insights, and (c) foster a collaborative community through a vibrant interdisciplinary training. With these activities, the GI T32 program aims to accelerate the pace of discovery and to advance the delivery of precision management in digestive disorders, which is directly aligned to NIDDK's goals of lessening the burden of these ailments. This Training Program leverages the continuing expansion of biomedical research at UCSD School of Medicine and its collaborating institutions to identify faculty mentors with GI-relevant research expertise, productive research programs, principled research conduct and outstanding training history from the Departments of Medicine, Family Medicine, Cellular & Molecular Medicine, Pediatrics, Pathology, Pharmacology, Surgery, and Pharmaceutical Sciences. The Training Program exposes the trainees as well as the faculty to the diversity of systems, approaches and technologies that are employed to investigate the complex biology and translational aspects of a range of GI disorders, including inflammatory bowel disease, functional GI disorders and motility, infectious diseases of the gut, gut microbiome, pancreatic and hepatobiliary disorders, nutrition and obesity, and malignancies of the digestive tract. In the past decade, pre-doc and post-doc trainees of this program have entered productive research careers with a success rate of 100% and ~90%, respectively, as research scientists and faculty. The UCSD GI T32 program Executive Committee, consisting of the Program Director, Associate Director, and an Internal Advisory Committee that selects and evaluates trainees and faculty as well as monitors progress within the Program. The UCSD GI T32 External Advisory Committee reviews program statistics and metrics to identify the strengths and weaknesses of training activities, trainees and faculty. With these activities and support from the UCSD School of Medicine, this program will continue to function as a nexus for GI-focused basic and translational research and training at UCSD.