Institutional Training Grant in Pediatric Gastroenterology

描述（由申请人提供）：本申请是科罗拉多丹佛大学和科罗拉多奥罗拉安舒茨医学院儿童医院儿科胃肠病学、肝病学和营养学机构培训计划（T32）的首次更新。该计划的总体目标是为不同群体的博士后学员提供特殊的监督培训经验，使他们能够发展或提高他们的研究技能和知识，为儿科胃肠病学或肝病学相关的研究事业做准备。该计划的基本原理是利用新的安舒茨医学院提供的新的物理和科学协同作用，一个杰出的致力于经验丰富的研究教师，以及大量的潜在申请人。提供两种研究培训途径，以培养基础实验室科学家或临床转化科学家。研究培训将集中在五个科学主题：儿科肝病的发病机制和治疗，儿科肠道疾病的免疫发病机制，粘膜免疫生物学，儿科肥胖和代谢综合征以及健康结果研究。T32教师由25人组成，拥有超过2700万美元的R 01，U 01或计划项目赠款资金和非常成功的培训记录。研究生课程、研讨会和多学科会议增加了基础研究经验。临床转化研究的学员将参加临床科学研究生课程的硕士学位，并将利用科罗拉多临床和转化科学研究所的基础设施。研究培训计划的设计是一个2-3年的计划，通常在亚专业奖学金的第二年开始，或在完成博士学位或同等学历之后。符合条件的候选人主要来自国家认可的儿科胃肠病学奖学金，其他学科的候选人包括儿科学，营养学和相关基础科学领域。受训人员在有指导和结构化的环境中接受2年或3年的培训，至少有80%的时间受到保护。教育和研究经验的质量将由学员，导师和执行委员会密切监测，并制定指标和持续改进流程。在过去3年完成T32培训的7名学员中，有5人拥有全职学术职位，并处于发展研究事业的早期阶段。请求继续保留4个培训职位，并在第2年增加第5个职位，以便进行3年培训。 公共卫生相关性：该T32培训计划通过培训下一代医生和博士科学家与儿童健康相关，他们通过科学发现将促进GI，肝病和营养障碍儿童的护理。本培训计划中对研究培训的投资将为学员成为未来的领导者，教师和导师奠定基础，他们将帮助指导未来的GI，肝病学和营养学方向。

DESCRIPTION (provided by applicant): This application is for the first renewal of the Institutional Training Program (T32) in Pediatric Gastroenterology, Hepatology and Nutrition at the University of Colorado Denver and The Children's Hospital at the Anschutz's Medical Campus in Aurora, Colorado. The overall goal of this program is to provide a diverse group of post-doctoral trainees with an exceptional supervised training experience to allow them to develop or enhance their research skills and knowledge in preparation for a pediatric gastroenterology or hepatology related research career. The underlying rationale for this program is to take advantage of new physical and scientific synergies provided by the new Anschutz Medical Campus, an outstanding committed experienced research faculty, and a large pool of potential applicants. Two pathways of research training are offered to produce Basic Laboratory Scientists or Clinical- Translational Scientists. Research training will be focused in five scientific themes: pathogenesis and treatment of pediatric liver disease, immunopathogenesis of pediatric intestinal disease, mucosal immunobiology, pediatric obesity and metabolic syndrome and health outcomes research. The T32 faculty comprises 25 individuals with over $27 million dollars in R01, U01 or program project grant funding and a highly successful training record. Basic research experiences are augmented by graduate courses, seminars and multidisciplinary meetings. Trainees in clinical-translational research will participate in the Masters Degree in the Clinical Sciences Graduate Program and will leverage the infrastructure of the Colorado Clinical and Translational Sciences Institute. The research training program is designed to be a 2-3 year program, generally beginning in the 2nd year of subspecialty fellowship or following completion of a PhD or equivalent. Eligible candidates are primarily drawn from the nationally recognized fellowship in Pediatric Gastroenterology, with the potential for candidates in other disciplines including neonatology, nutrition and related basic science fields. Trainees are provided a minimum of 80% protected time for 2 or 3 years of training in a mentored and structured environment. The quality of the educational and research experiences will be closely monitored by the trainees, mentors and Executive Committee with defined metrics and ongoing improvement processes. Of the 7 trainees who have completed the T32 training in the past 3 years, 5 have full-time academic positions and are very early in developing their research careers. The continuation of 4 training positions is requested with the addition of a 5th position in year 2 to allow for 3 years of training. PUBLIC HEALTH RELEVANCE: This T32 Training Program is relevant to child health by training the next generation of physician and PhD scientists who through scientific discovery will advance the care of children with Gl, hepatology and nutritional disorders. The investment in research training in this Training Program will provide a foundation for the trainees to become the future leaders, teachers and mentors who will help guide the direction of Gl, hepatology and nutrition in the future.