Translating Obesity, Metabolic Dysfunction and Comorbid Disease States

项目摘要 肥胖率在青少年、成年人和老龄化人群中持续上升， 慢性疾病和共病的疾病状况。肥胖及相关慢性病 条件困扰着我们的医疗保健系统，对生活质量产生负面影响，并造成可怕的经济损失。 社会肥胖诱导的病理显著增加了代谢疾病状态、心血管疾病和心血管疾病的风险。 功能障碍、慢性肾病、严重的矫形限制和各种形式的癌症。肥胖还 增加慢性衰弱性疼痛和精神健康障碍（压力、抑郁、焦虑）的风险。 过去30年的证据表明，我们目前的医疗保健系统不能有效预防或 治疗肥胖和相关并发症。传统的方法在很大程度上是无效的， 他们专注于单一模式的干预（运动，饮食，药理学）或没有有效地 从实验室到诊所，或者从诊所到人群。新的研究驱动型解决方案， 连接基础生物医学科学、临床和人口健康研究的疗法， 对齐并解决肥胖和共病疾病条件下的多模态结构， needed.因为肥胖是许多疾病和共病的核心，而且越来越普遍， 我们认为肥胖应该成为下一代科学家培训的核心内容。我们的T32 一项名为“转化肥胖、代谢功能障碍和共病状态”的提案将提供 对博士前研究生进行基础研究培训。T32培训计划将有4个预- 博士生提供了支持~2年，并将努力准备学员与不同的工作 学科和培养协同和转化的研究团队。学员将由两个基本的 科学和临床教师，并将与内部咨询委员会与基础，临床， 翻译科学知识。学员将参加一个独特的培训计划，包括一个多样化的集 活动（研讨会，会议，教学课程工作）和定制计划，以满足需求和目标， 每一个实习生堪萨斯大学医学中心（KUMC）拥有必要的资源和科学 该计划的环境包括翻译研究人员的既定文化， 由联邦政府资助的研究肥胖和肥胖相关共病的研究者团体 与该地区领先的医疗保健提供商（堪萨斯大学）协同合作， 卫生系统），并获得受肥胖严重影响的研究参与者的多样化人群 （城市、农村、各种社会经济和族裔群体）。我们希望我们的T32将提供独特的培训， 博士前候选人，促进新的合作研究网络，并导致新的科学发现， 肥胖症的治疗和预防。

PROJECT SUMMARY Obesity rates continue to rise in adolescents, adults, and aging populations leading to greater rates of chronic disease and comorbid disease conditions across the lifespan. Obesity and associated chronic disease conditions plague our healthcare system, negatively influence quality of life, and exact a terrible financial toll on society. Obesity induces pathologies that dramatically increase risk of metabolic disease states, cardiovascular dysfunction, chronic kidney disease, significant orthopedic limitations, and various forms of cancer. Obesity also increases risk for chronic debilitating pain conditions and mental health disorders (stress, depression, anxiety). Evidence over the last 3 decades shows that our current healthcare system is not effective in preventing or treating obesity and associated complications. Traditional methodologies have largely been ineffective because they have focused on single mode interventions (exercise, diet, pharmacology) or have not been effectively translated from the bench to the clinic or the clinic to population level. New research-driven solutions and therapies that bridge basic biomedical science, clinical, and population health research that are synergistically aligned and address the multi-modal constructs underlying obesity and co-morbid disease conditions are needed. Because obesity is central to so many diseases and comorbid conditions, and is increasingly prevalent, we argue that obesity should be a centerpiece in the training for the next generation of scientists. Our T32 proposal entitled “Translating Obesity, Metabolic Dysfunction and Comorbid Disease States” will provide foundational research training to predoctoral graduate students. The T32 training program will have 4 Pre- Doctoral trainees provided support for ~2 years and will strive to prepare trainees to work with divergent disciplines and foster synergistic and translational research teams. Trainees will be co-mentored by both basic science and clinical faculty and will interact with an internal advisory committee with basic, clinical, and translational scientific expertise. Trainees will take part in a unique training program involving both a diverse set of activities (seminars, meetings, didactic course work) and customized plans that meet the needs and goals of each trainee. The University of Kansas Medical Center (KUMC) has the necessary resources and scientific environment for this program including an established culture of translational researchers, a well-established community of federally funded investigators studying obesity and obesity associated comorbid disease conditions across the lifespan, synergy with the leading healthcare provider in the area (University of Kansas Health System), and access to a diverse population of research participants significantly impacted by obesity (urban, rural, various socioeconomic and ethnic groups). We expect that our T32 will provide unique training for predoctoral candidates, foster new collaborative research networks, and lead to new scientific discoveries for the treatment and prevention of obesity.