The investigation of an unconventional Human Leukocyte Antigen molecule
The investigation of an unconventional Human Leukocyte Antigen molecule
批准号:
DE210101479
负责人:
Dr Emma Grant
金额:
$31.72万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Early Career Researcher Award
财政年份:
2021
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2021-01-01 至 2024-09-29
中文摘要
该项目旨在研究一种独特的、研究不足的表面分子(HLA-E)。免疫系统由一组复杂的分子激活和调节,包括细胞表面上存在的HLA分子,其告知免疫系统感染。因此,该项目希望通过利用尖端和多学科的方法在细胞生物学和免疫学领域产生新的知识。该项目的预期成果包括产生关于这种非常规分子及其与免疫细胞相互作用的新知识。这将通过定义HLA-E在免疫系统中的非常规作用产生重大影响,这可能会为未来的疫苗或治疗研究提供建议。
英文摘要
This project aims to characterise a unique and understudied surface molecule (HLA-E). The immune system is activated and regulated by a complex set of molecules including HLA molecules present on the cell surface that inform the immune system of infection. Therefore, this project expects to generate new knowledge in the areas of cellular biology and immunology by utilising a cutting-edge and multi-disciplinary approach. Expected outcomes of this project include the generation of new knowledge of this unconventional molecule and its interaction with immune cells. This should provide significant impacts by defining the non-conventional role of HLA-E within the immune system, which may advise future research into vaccines or therapeutics.
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会议论文
Identification and characterisation of HLA-E restricted influenza A virus-specific CD8+ T cells
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批准号:nhmrc : GNT1110429
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项目类别:Early Career Fellowships
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资助金额:$35.42万
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财政年份:2016
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负责人:Dr Emma Grant
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依托单位:
Identification and characterisation of HLA-E restricted influenza A virus-specific CD8+ T cells
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批准号:nhmrc : 1110429
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项目类别:Early Career Fellowships
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资助金额:$24.47万
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财政年份:2016
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负责人:Dr Emma Grant
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依托单位:
Understanding influenza-specific T cell immunity in the Indigenous and non-Indigenous populations
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批准号:nhmrc : 1055323
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项目类别:Postgraduate Scholarships
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资助金额:$3.28万
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财政年份:2013
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负责人:Dr Emma Grant
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依托单位:
国内基金
海外基金
铁磁性超导体的微观电子态和相图的理论研究
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批准号:10574063
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项目类别:面上项目
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资助金额:26.0万元
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批准年份:2005
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负责人:李俊
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依托单位: