Islet & Physiology Core

摘要(胰岛和生理核心) 胰岛和生理学核心支持印第安纳州糖尿病研究中心(IDRC)的总体使命 促进协作，支持培训，促进糖尿病及相关代谢领域的前沿研究 通过在啮齿动物胰岛隔离中提供全面和最先进的服务来解决疾病；斑马鱼，啮齿动物， 猪和人类胰岛的特性；人、啮齿动物和猪胰岛移植；以及啮齿动物代谢 表型鉴定。小岛和生理学核心支持印第安纳大学IDRC调查人员的工作 医学院(IUSM)及其附属机构，与成员密切合作，为 围绕包括帮助实验设计、有效执行实验以及 协助数据分析和解释。Core既为有经验的用户服务，也为新手用户服务 并作为一个重要的渠道，为那些没有进入现场的调查人员提供便利 传统上研究胰岛或进行新陈代谢研究。除了咨询和试验之外 服务，核心为那些希望将专门技术重新纳入 他们自己的实验室。核心主任是C.Evans-Molina博士，副主任是S.Tersey博士， 助理主任是R.安德森博士。领导层由一组技术人员协助，并由以下人员提供建议 一个顾问委员会。该核心与IDRC翻译核心、显微镜核心、系统和 Informatics Core和Swin Core满足了我们用户群的实验需求，同时也秉承了 严谨、可重复性、精细化和简化的最高标准。该核心将实现以下目标： (1)为红十字国际中心的调查人员提供优质的啮齿动物小岛，并方便采购 人和猪胰岛及胰腺组织进行分析。 (2)提供最先进的人类、啮齿动物、斑马鱼和猪胰岛和胰腺的特征 服务。 (3)提供最先进的啮齿动物新陈代谢分析，包括评估血糖和胰岛素 耐力、身体成分、能量消耗、活动水平和食物摄入量。 (4)提供切合双方经验的咨询服务和培训 使用者和使用者是糖尿病和新陈代谢研究的新手。 (5)。确保核心服务不断发展，以满足IDRC调查员的需求并与新的 该领域的发展

ABSTRACT (ISLET & PHYSIOLOGY CORE) The Islet & Physiology Core supports the overall mission of the Indiana Diabetes Research Center (IDRC) to foster collaboration, support training, and promote cutting edge research in diabetes and related metabolic disorders by providing comprehensive and state-of-the art services in rodent islet isolation; zebrafish, rodent, swine, and human islet characterization; human, rodent, and swine islet transplantation; and rodent metabolic phenotyping. The Islet and Physiology Core supports the work of IDRC investigators from Indiana University School of Medicine (IUSM) and its affiliated institutions, working closely with members to provide “wrap- around” services that include assistance with experimental design, efficient execution of experiments, and assistance with data analysis and interpretation. The Core serves both experienced as well as novice users and functions as an important conduit for facilitating entry into the field for investigators who have not traditionally worked with islets or performed metabolic research. In addition to consultative and experimental services, the Core provides training for investigators who wish to incorporate specialized techniques back into their own lab. The Director of the Core is Dr. C. Evans-Molina, the Associate Director is Dr. S. Tersey, and the Assistant Director is Dr. R. Anderson. The leadership is assisted by a crew of technical staff and advised by an Advisory Board. The Core closely interfaces with the IDRC Translation Core, Microscopy Core, Systems & Informatics Core, and Swine Core to meet the experimental needs of our user base, while also adhering to the highest standards of rigor, reproducibility, refinement, and reduction. The Core will achieve the following aims: (1) To provide IDRC investigators with high quality rodent islets and facilitate the procurement of human and swine islets and pancreatic tissues for analysis. (2) To provide state-of-the-art human, rodent, zebrafish and swine islet and pancreas characterization services. (3) To provide state-of-the art rodent metabolic analysis, including assessment of glucose and insulin tolerance, body composition, energy expenditure, activity levels, and food intake. (4) To provide consultation services and training that is tailored to fit the needs of both experienced users and users who are new diabetes and metabolic research. (5). To ensure that Core services evolve to meet IDRC investigator needs and keep pace with new developments in the field