Islet Core

摘要(小岛核心) 小岛核心的专门小岛生物学专业知识将使红十字国际研究中心的调查人员能够 获得高质量的啮齿动物胰岛和胰腺的定量结构和功能研究， 和人类。Islet核心人员将与IDRC调查人员密切合作，制定实现以下目标的战略 针对特定动物/人体细胞模型系统的需要而定制的完整数据集。小岛核心将 与啮齿动物、显微镜和翻译岩心协调，提供最全面的分析，同时 利用最少的动物数量，努力最大限度地坚持IACUC的小岛核心减少政策 将以下列方式本着红十字国际委员会的使命精神发挥作用：1)这个岛屿核心的能力是独特的 从猪核获得胰腺/LSET，特别是代谢综合征模型 奥萨巴猪，直截了当地谈到了培养新知识的观点。2)小岛核心还将提供 独特的胰岛移植服务将与显微镜核心的新的活体成像相吻合 能力，也培养新的知识，并支持这些新方法的培训。3)小岛核 坚持糖尿病翻译研究的承诺，通过以下方式向所有IDRC用户提供人类胰岛 作为核心设施签订了合同，不再需要个别研究人员申请和批准 单独用于IIDP人类胰岛通道。这将促进胰岛核心在胰岛转导方面的专业知识 分泌物和成像方式。最后，小岛核心以其在双相功能方面的卓越而闻名 描述了所有类型的小岛，为许多现有和规划中的小岛提供了宝贵的解释价值 肥胖和糖尿病的啮齿动物模型。小岛核心将实现以下目标： (1)为红十字国际研究中心的调查人员提供优质的啮齿动物、猪和人岛 (2)为研究中心的调查人员提供最先进的胰岛和胰腺定性服务 (3)为红十字国际研究中心的调查人员提供胰岛分离和分析方面的培训 (4)确保核心服务的演变，以满足红十字国际研究中心研究基地的持续需求 小岛核心将作为IDRC的宝贵资源，为调查人员提供特定于小岛的 在相对较少的水平上表征胰岛功能所需的专业知识和培训 实验室。

Abstract (Islet Core) The specialized islet biology expertise of the Islet Core will provide IDRC investigators with the capability to obtain high quality quantitative structural and functional studies of islets and pancreata from rodents, swine, and humans. Islet Core personnel will work closely with IDRC investigators to strategize attainment of complete data sets tailored to the needs of the particular animal/human cell model system. The Islet Core will coordinate with Rodent, Microscopy and Translation Cores to provide the most comprehensive analyses while utilizing the fewest number of animals, in effort to adhere best to the reduction policies of IACUC The Islet Core will function in the spirit of the mission of the IDRC in the following ways: 1)This Islet Core is unique in its ability to interface and obtain pancreata/lslets from the Swine Core, and in particular the metabolic-syndrome model Ossabaw pig, speaking directly to the point on fostering new knowledge. 2) The Islet Core will also provide unique Islet transplantation services which will dovetail with the Microscopy Core's novel intravital imaging capacity, also fostering new knowledge and supporting training in these novel methodologies. 3) The Islet Core adheres to the pledge for translational research in diabetes, by offering human islets to all IDRC users by having contracted as a core facility, obviating the need for individual researchers to apply for and be approved individually for IIDP human islet access. This will promote the Islet Core's expertise in islet transduction for secretion and imaging modalities. Lastly, the Islet Core is renowned for its excellence in biphasic functional characterizations of all types of islets, providing invaluable interpretive value to the many existing and planned rodent models of obesity and diabetes. The Islet Core will achieve the following aims: (1) To provide IDRC investigators with high quality rodent, swine and human islets (2) To provide IDRC investigators with state-of-the-art islet and pancreas characterization services (3) To provide IDRC investigators with training in islet isolation and analysis (4) To ensure evolution of core services to meet the ongoing needs of the IDRC Research Base The Islet Core will serve as an invaluable resource for the IDRC, providing investigators with the islet-specific expertise and training necessary to characterize islet function at a level that is limited to a relatively few laboratories.