Islet Core

胰岛核心

• 批准号: 9105738
• 负责人: Carmella Evans-Molina
• 金额: $ 17.16万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9105738
• 关键词: Animals; Basic Science; Biological Models; Biology; Cell model; Collaborations; Contracts; Core Facility; Data Set; Diabetes Mellitus; Ensure; Evolution; Family suidae; Fostering; Human; Human Resources; IACUC; Indiana; Individual; Islets of Langerhans Transplantation; Knowledge; Laboratories; Metabolic Diseases; Metabolic syndrome; Methodology; Microscopy; Mission; Modeling; Obesity; Pancreas; Policies; Research; Research Personnel; Resources; Rodent; Rodent Model; Services; Techniques; Training; Training Support; Translational Research; Translations; Work; abstracting; base; imaging modality; intravital imaging; islet; meetings; novel

Abstract (Islet Core) The specialized islet biology expertise of the Islet Core will provide IDRC investigators with the capability to obtain high quality quantitative structural and functional studies of islets and pancreata from rodents, swine, and humans. Islet Core personnel will work closely with IDRC investigators to strategize attainment of complete data sets tailored to the needs of the particular animal/human cell model system. The Islet Core will coordinate with Rodent, Microscopy and Translation Cores to provide the most comprehensive analyses while utilizing the fewest number of animals, in effort to adhere best to the reduction policies of IACUC The Islet Core will function in the spirit of the mission of the IDRC in the following ways: 1)This Islet Core is unique in its ability to interface and obtain pancreata/lslets from the Swine Core, and in particular the metabolic-syndrome model Ossabaw pig, speaking directly to the point on fostering new knowledge. 2) The Islet Core will also provide unique Islet transplantation services which will dovetail with the Microscopy Core's novel intravital imaging capacity, also fostering new knowledge and supporting training in these novel methodologies. 3) The Islet Core adheres to the pledge for translational research in diabetes, by offering human islets to all IDRC users by having contracted as a core facility, obviating the need for individual researchers to apply for and be approved individually for IIDP human islet access. This will promote the Islet Core's expertise in islet transduction for secretion and imaging modalities. Lastly, the Islet Core is renowned for its excellence in biphasic functional characterizations of all types of islets, providing invaluable interpretive value to the many existing and planned rodent models of obesity and diabetes. The Islet Core will achieve the following aims: (1) To provide IDRC investigators with high quality rodent, swine and human islets (2) To provide IDRC investigators with state-of-the-art islet and pancreas characterization services (3) To provide IDRC investigators with training in islet isolation and analysis (4) To ensure evolution of core services to meet the ongoing needs of the IDRC Research Base The Islet Core will serve as an invaluable resource for the IDRC, providing investigators with the islet-specific expertise and training necessary to characterize islet function at a level that is limited to a relatively few laboratories.

摘要（胰岛核心） 胰岛核心的专门胰岛生物学知识将为IDRC研究人员提供以下能力： 从啮齿动物，猪， 还有人类Islet核心人员将与IDRC调查人员密切合作， 根据特定动物/人细胞模型系统的需要定制的完整数据集。核心岛将 与啮齿动物、显微镜和翻译核心协调，提供最全面的分析， 利用最少数量的动物，努力最好地遵守IACUC的减排政策。 将以以下方式本着IDRC的使命精神发挥作用：1）这个小岛核心的能力是独一无二的 连接并从猪核心获得胰腺/胰岛，特别是代谢综合征模型 奥萨博猪，说话直接点上培养新的知识。2)核心岛还将提供 独特的胰岛移植服务，将与显微镜核心的新型活体成像相吻合 能力，也促进新的知识和支持这些新方法的培训。3)核心岛 坚持糖尿病转化研究的承诺，通过向所有IDRC用户提供人类胰岛， 作为一个核心设施承包，避免了个人研究人员申请和批准的需要 单独用于IIDP人类胰岛获取。这将促进胰岛核心在胰岛转导方面的专业知识， 分泌和成像模式。最后，胰岛核心以其卓越的双相功能而闻名。 所有类型的岛屿的特征，提供了宝贵的解释价值，许多现有的和计划 肥胖和糖尿病的啮齿动物模型。Islet Core将实现以下目标： (1)为IDRC研究人员提供高质量的啮齿动物、猪和人类胰岛 (2)为IDRC研究者提供最先进的胰岛和胰腺表征服务 (3)为IDRC研究人员提供胰岛分离和分析方面的培训 (4)确保核心服务的发展，以满足IDRC研究基地的持续需求 胰岛核心将作为IDRC的宝贵资源，为研究人员提供胰岛特异性 专门知识和必要的培训，以表征胰岛功能的水平，这是有限的相对少数 laboratories.