Indiana Diabetes Research Center

摘要（总体中心） 印第安纳州糖尿病研究中心（IDRC）的使命是促进知识，支持培训， 促进糖尿病和相关代谢紊乱及其并发症的基础和转化研究。 IDRC的一个主要重点是糖尿病“下一代”的培训和发展 研究员这一重点涉及由IDRC领导的全州范围的努力，其中包括提供资源 （通过研究核心），财政支持和指导（通过试点和可行性方案， 机构基金），并建立一个合作的糖尿病生态系统（通过丰富计划）， 印第安纳州大学医学院及其附属研究机构的研究人员正在迅速增加 在印第安纳州（普渡大学，印第安纳州大学-普渡大学在印第安纳波利斯，印第安纳州大学 布卢明顿和印第安纳州生物科学研究所）。IDRC一直是增长的催化剂 自2015年该奖项获得资助以来，糖尿病研究基地的收入增长了47%。IDRC由一个 研究基地由94名高度合作的研究人员组成，他们代表4个研究主题：细胞和分子 代谢;糖尿病和肥胖症的并发症;胰岛功能和存活;糖尿病的营养和生理 和肥胖。总的来说，这组研究人员每年从NIH获得4670万美元的指导，其中 50%（2300万美元）来自NIDDK。这些研究人员的研究计划是由5个国家的- 艺术研究核心（显微镜，胰岛和生理学，翻译，猪，系统和信息学核心）。 一个由6个T32培训赠款支持的充实方案将加强学习和发现。一名飞行员和 可行性计划将通过为非常有前途的年轻研究人员提供资金来发展研究基地。 一个行政核心将监督IDRC的治理，并将接受执行人员的意见 委员会、内部咨询委员会和世界知名的外部咨询委员会 糖尿病/代谢研究领导者。发展研究中心的目标是： (1)通过利用研究核心促进高影响力的科学发现， 在糖尿病研究中合作和使用最先进的方法和人体研究; (2)加强高度协作的环境，促进学习和鼓励互动 调查人员之间; (3)支持培训和创新研究的一个新兴池的高超的研究人员与 有潜力成为未来糖尿病研究的领导者; (4)建立和加强糖尿病研究基地，支持基础设施，以确保持续增长 和创新，并与当地社区合作，提高糖尿病意识和参与度。

ABSTRACT (OVERALL CENTER) The mission of the Indiana Diabetes Research Center (IDRC) is to foster knowledge, support training, and promote basic and translational research in diabetes and related metabolic disorders, and their complications. A major focus of the IDRC has been the training and development of the “next generation” of diabetes researcher. This focus has involved a state-wide effort led by the IDRC that has included resource provision (through the Research Cores), financial support and mentoring (through the Pilot and Feasibility Program and institutional funds), and creation of a collaborative diabetes ecosystem (through the Enrichment Program) for a burgeoning pool of investigators at Indiana University School of Medicine and its affiliated research institutions in Indiana (Purdue University, Indiana University-Purdue University in Indianapolis, Indiana University Bloomington, and the Indiana Biosciences Research Institute). The IDRC has been the catalyst for the growth of the Diabetes Research Base by 47% since the funding of this award in 2015. The IDRC consists of a Research Base of 94 highly collaborative investigators who represent 4 research themes: Cellular & Molecular Metabolism; Complications of Diabetes & Obesity; Islet Function & Survival; Nutrition & Physiology of Diabetes and Obesity. Collectively, this group of investigators brings in $46.7M in annual directs from the NIH, of which 50% ($23M) is from NIDDK. The research programs of these investigators is be augmented by 5 state-of-the- art Research Cores (Microscopy, Islet & Physiology, Translation, Swine, and Systems & Informatics Cores). An Enrichment Program, supported by 6 T32 training grants, will enhance learning and discovery. A Pilot and Feasibility Program will grow the Research Base by providing funding to highly promising young investigators. An Administrative Core will oversee governance of the IDRC, and will receive input from an Executive Committee, an Internal Advisory Board, and an External Advisory Board of world-renowned diabetes/metabolism research leaders. The Aims of the IDRC will be to: (1) Promote high impact scientific discoveries by leveraging Research Cores that facilitate collaborations and the use of state-of-the-art methodologies and human studies in diabetes research; (2) Enhance a highly collaborative environment that promotes learning and encourages interaction among investigators; (3) Support the training and innovative research of a burgeoning pool of superb investigators with the potential to become future leaders in diabetes research; (4) Build and strengthen the diabetes research base, support infrastructure to ensure ongoing growth and innovation, and engage with the local community to raise diabetes awareness and involvement.