Basic Science Core - Animal models

IN-TRAC动物核心摘要 动物模型中心将建立一个培训计划，向所有IN-TRAC参与者介绍结核病领域 使用各种动物模型，可以将计算机和体外发现转化为潜在的应用， 人类德克萨斯州生物医学主办西南国家灵长类动物研究中心（SNPRC），并已开发出 大型NHP计划，包括空气生物学，分子生物学和各种成像平台， 动物生物安全3级（ABSL 3）这些将是动物核心的基础。具体目标1： 开展一项关于使用动物进行研究和替代品的教育计划。使用动物 在研究中需要考虑三个R（减少，替换，改进）。所有核心预算资源调拨目标参与者 在实验设计过程中，将接受关于三个R的考虑因素的培训，选择适当的 模型来测试他们的特定假设，以及可用的或正在开发的替代系统， 生物医学研究中的动物替代。具体目标2：利用结核病小鼠模型， 研究发病机理和测试新疗法和疫苗。小鼠模型一直是 结核病研究，仍然是了解结核病免疫发病机制和筛选药物的有用工具， 结核病疫苗将向IN-TRAC参与者介绍各种结核病可用的鼠标资源 研究，并将在理论和实践中如何设计和使用啮齿动物进行研究，以及如何 用科学的严谨性来解释实验数据具体目标3：利用结核病的NHP模型进行研究 发病机制和测试新的疗法和疫苗。德克萨斯生物医学公司拥有独特的资源 SNPRC可以为IN-TRAC参与者提供在结核病研究中使用NHP的深入培训。IN- 将向TRAC参与者介绍可用于结核病研究的各种NHP资源，并进行理论培训 如何设计和使用NHP进行研究，以及如何解释实验数据的实践 科学严谨完成动物模型核心后，参与者将能够有效地解释 使用啮齿动物和NHP（以及其他动物模型，部分通过外部），设计 实验来验证他们自己的假设，并参与使用动物的结核病研究。

IN-TRAC ANIMAL CORE ABSTRACT The Animal Model Core will establish a training program to introduce all IN-TRAC participants to the TB field using a variety of animal models that can translate in silico and in vitro findings into potential application to humans. Texas Biomed hosts the Southwest National Primate Research Center (SNPRC) and has developed large NHP programs that incorporate aerobiology, molecular biology and a variety of imaging platforms within the Animal Biosafety Level 3 (ABSL3). These will be the foundation of the Animal Core. SPECIFIC AIM 1: Conduct an educational program in the use of animals for research, and alternatives. The use of animals in research requires consideration of the three R’s (reduction, replacement, refinement). All IN-TRAC participants will receive training in the considerations of the three R’s during experimental design, selection of appropriate models to test their specific hypothesis, and the alternate systems available or in development for the replacement of animals in biomedical research. SPECIFIC AIM 2: Leveraging the mouse model of TB to study pathogenesis and testing of new therapies and vaccines. The mouse model has been a mainstay for TB research and remains a useful tool for understanding TB immuno-pathogenesis and for screening drugs and vaccines for TB. IN-TRAC participants will be introduced to a variety of mouse resources available for TB research, and will be trained in theory and practice of how to design and conduct studies using rodents, and how to interpret experimental data with scientific rigor. SPECIFIC AIM 3: Leveraging the NHP model of TB to study pathogenesis and testing of new therapies and vaccines. Texas Biomed has a unique resource in the SNPRC that can provide IN-TRAC participants with an in depth training in the use of NHPs in TB research. IN- TRAC participants will be introduced to a variety of NHP resources available for TB research, and train in theory and practice of how to design and conduct studies using NHPs, and how to interpret experimental data with scientific rigor. At the completion of the Animal Model Core, participants will be able to effectively interpret published data that use rodents and NHP (and other animal models, in part through externships), design experiments to test their own hypothesis, and participate in TB research that uses animals.