Enabling sustainable biomanufacturing by reducing the use of single use plastics in biopharma with the biocomputer platform

生物计算机是生物计算机的发明者，生物计算机是一个高度集成和可编程的自动化平台，用于按需生产基于生物的产品和数据。生物计算机将生物起源的成分，如细胞、核酸、蛋白质和生物试剂，加工成有用的产品，如疗法。生物计算机平台可以从一个公共设备运行多个应用程序。生物计算机由四个核心流体芯片组成，可以根据生物处理应用程序或协议进行重新配置；使该系统能够用于已经通过客户项目展示的多种应用程序，例如先进的细胞疗法和小规模批量mRNA疫苗制造。我们面临的下一个紧迫挑战是支持我们的客户过渡到可持续的生物处理。最近，生物制药行业发生了转变，从耐用材料转向一次性使用的生物反应器。这一变化是由工艺灵活性、易于使用、占地面积小和无菌保证推动的。然而，它大幅增加了塑料垃圾。通过生物计算机平台，我们希望为我们的客户提供一次性系统所提供的所有灵活性，并通过以可持续的方式集成就地清洁(CIP)和就地灭菌(SIP)来增加可重用性。生物计算机的架构灵感来自半导体行业，旨在支持灵活制造。该系统集成了CIP和SIP，可作为耐用的长期基础设施使用。作为生物计算机标准架构的一部分，我们集成了一个“洗涤电路”。洗涤循环包括一个体系结构，用于将溶液分布在系统周围，以对其进行清洁和消毒，以便重复使用。此外，我们使用用于生物处理的相同基础设施(例如，我们希望通过这款A4I来解决两个主要挑战：(A)验证我们的CIP和SIP的稳健性，以避免周期之间的微生物污染和产品交叉污染；(B)确定3D打印生物反应器模块的耐用性。作为一个精益的初创公司，生物没有足够的验证和表征的内部资源或设备，也没有财务资源来在商业基础上支付合作伙伴，如NPL和敏锐的工作。只有通过该项目与外部专业人员合作，才能对CIP和SIP的健壮性进行生物优化和验证，从而允许系统在多个生物制造周期和应用中重复使用，从而实现可持续的生物制造。

BiologIC is the inventor of the biocomputer, a highly integrated and programmable automation platform for producing bio-based products and data on demand. The biocomputer processes components of biological origin, such as cells, nucleic acids, proteins, and biological reagents, into useful products such as therapies. The biocomputer platform can run multiple applications from a common device.The biocomputer comprises four core fluidic chips that can be reconfigured depending on the bioprocessing application or protocol; enabling the system to be used for multiple applications already demonstrated with customer projects, such as advanced cell therapies and small-scale batch mRNA vaccine manufacturing.The next imperative challenge that we face is supporting our customers in their transition to sustainable bioprocessing. Recently there has been a shift in the biopharma industry to move from durables to single use bioreactors. This change was driven by process flexibility, ease to use, small footprint and sterility assurance. However, it has substantially increased plastic waste. With the biocomputer platform we want to provide our customers all the flexibility that single-use systems offer with the additional capability of reusability by integrating cleaning in place (CIP) and sterilisation in place (SIP) in a sustainable way.The biocomputer's architecture inspired by the semiconductor industry is designed to support flexible manufacturing. The system integrates CIP and SIP enabling use as durable, long-term infrastructure. As part of the biocomputer standard architecture we have integrated a "wash circuit". The wash cycle comprises an architecture for distributing solutions around the system to clean and sterilise it for reuse. Additionally, we make use of the same infrastructure used for bioprocessing (eg. impeller, heater) to enhance the cleaning process.There are two main challenges that we are looking to solve with this A4I: (a) the validation of the robustness of our CIP and SIP to avoid microbiological contamination and product cross contamination between cycles and (b) to determine the durability of the 3D printed bioreactor modules.As a lean start up, BiologIC does not have internal resources or equipment for sufficient validation and characterisation or financial resources to pay partners such as NPL and ASTUTE on a commercial basis for the work. Only by collaborating with external expertise through this project can BiologIC optimise and validate the robustness of the CIP and SIP which enable sustainable biomanufacture by allowing re-use of the system for multiple biomanufacturing cycles and applications.