Multidisciplinary Research Fellowship in Alzheimer's disease and Related Dementias

摘要 这是加州大学旧金山分校行为神经学培训计划第三次申请T32资金 (BNTP)，由霍华德·罗森和布鲁斯·米勒博士联合执导。BNTP于1999年在加州大学旧金山分校成立， 加州大学旧金山分校记忆和衰老中心(MAC)培训临床研究人员的行为神经学和 神经退行性疾病。这项T32计划于2005年资助，使新兴研究人员能够获得 对神经退行性变的临床、流行病学、遗传学和分子特征的综合理解 是世界上为数不多的为非阿尔茨海默氏症患者提供强化培训的项目之一 痴呆症和非遗忘型AD。该项目的目标是培养博士后临床研究人员 从事神经退行性研究。该计划向MD神经科医生、老年病学家和 完成住院医师培训的精神科医生。我们计划的一个核心要素是对 痴呆亚型和导致神经变性的特定蛋白的预测。我们的培训是经过精心设计的 向研究员传授评估和量化各种蛋白质和其他生物因素的影响的技能 使用临床评估和实验室方法导致痴呆症的人。培训时间超过两年。 第一年是我们中心的四个临床研究项目的研究轮换，包括我们的 我们的阿尔茨海默病研究项目额颞部痴呆症项目资助，我们的快速 进行性痴呆症计划和我们的临床试验计划。在这一年里，研究员们开始开发 他们的研究项目与其中一位项目导师一起进行，并培养科学写作、演示和 使用我们的临床和影像数据库中的档案数据进行数据分析。在第二年，研究员是 由于有更多的非结构化时间来继续他们的研究项目和拨款申请计划，以支持他们的 未来的临床研究生涯。多年来，我们的项目加强了与加州大学旧金山分校的关系 精神病学和老年病学，这影响了我们的研究、招募和培训方法。二十- 该T32直接支持了9名研究员，但通过T32计划开发的基础设施 为更多博士后研究员的教育做出了贡献。在即将到来的周期中，培训方案 将包括额外的讲授课程，涵盖健康、健康经济和政策的社会决定因素， 以及领导力培训。

ABSTRACT This is the third renewal application requesting T32 funding for the UCSF Behavioral Neurology Training Program (BNTP), co-directed by Drs. Howard Rosen and Bruce Miller. The BNTP was established at UCSF in 1999 within the UCSF Memory and Aging Center (MAC) to train clinical researchers in behavioral neurology and neurodegenerative disease. Funded in 2005, this T32 program allows emerging researchers to gain an integrated understanding of the clinical, epidemiological, genetic, and molecular features of neurodegenerative diseases, and is one of the few programs in the world that provides intensive training on the non-Alzheimer’s dementias and non-amnestic forms of AD. The goal of the program is to train postdoctoral clinical researchers for a career in neurodegenerative research. The program is open to MD neurologists, geriatricians and psychiatrists who have completed a residency. A core element of our program is accurate classification of dementia subtypes and prediction of the specific proteins causing neurodegeneration. Our training is designed to impart fellows with the skills to evaluate and quantify the effects of various proteins and other biological factors that cause dementia using clinical assessment and laboratory methods. Training takes place over two years. The first year consists of research rotations through four clinical research programs at our center including our program project grant on frontotemporal dementia, our Alzheimer’s disease research program, our rapidly progressive dementia program and our clinical trials program. During this year, fellows begin development of their research project with one of the program mentors and develop skills in scientific writing, presentation, and in data analysis using archival data from our clinical and imaging databases. In the second year, fellows are given more unstructured time to continue their research project and plan for grant submissions to support their future career in clinical research. Over the years, our program has strengthened relationships with UCSF Psychiatry and Geriatrics, and this has influenced our research, recruitment, and approach to training. Twenty- nine fellows have been supported directly by this T32, but the infrastructure developed through the T32 program contributes to the education of many additional postdoctoral fellows. In the upcoming cycle the training program will include additional didactic sessions covering social determinants of health, health economics and policy, along with leadership training.