Older Americans Independence Center

总体情况：项目摘要 这是约翰霍普金斯大学老年美国人独立中心(JHU)的续签申请 OAIC)。在2013年开始的本轮周期中，OAIC培育了广泛的成就， 对121份出版物和调查结果作出贡献，为48项额外赠款提供资金，重点放在 虚弱和老化。OAIC的研究人员试图通过这项研究促进老年人的独立性 虚弱的病因和临床后果，并通过将这一知识转化为 开发新的、以脆弱为重点的诊断、治疗和预防策略。这项提议旨在 通过以下具体目标实现这些目标：1)激发和发展有效的、以脆弱为重点的 跨学科研究计划；2)将关注脆弱性的知识转化为有针对性的 帮助老年人保持独立性的预防和治疗战略；3)提供有重点的和 对有兴趣发展职业生涯的初级调查人员提供与脆弱性相关的培训和指导 专注于维护老年人的独立性；4)向OAIC支持的调查人员提供 生物统计、生物和临床科学领域最高质量的跨学科专业知识和基础设施 与脆弱的研究相关；5)支持创新方法、研究战略的发展 和对脆弱性研究至关重要的技术；以及6)吸引优秀的调查人员和受训人员 来自约翰·霍普金斯大学的脆弱研究，并促进他们的科学在当地和 全国范围内。研究教育部分(REC)和试点研究核心将提供培训、指导、 以及为受支持的研究人员的研究项目提供咨询和物质支持。高度集成 侧重于生物统计学、生物机制以及临床翻译和招聘的资源核心将 为受支持的调查人员提供跨学科的专业知识、培训、指导、协助和 执行突出的以脆弱性为重点的基础、临床和转化性研究所需的服务。一种新的 信息传播核心将扩展由研究人员开发的关于脆弱性的发现的范围 该组织和其他组织通过一个新的网站，提供导航并方便地访问关于脆弱性的调查结果， 创新教育举措，与科学和专业组织建立新的伙伴关系 实践社区和外联努力的一部分。这个OAIC将继续由一个长期的， 跨学科、有成就且高度可见的领导团队，他们继续开发持续的 对下一代脆弱科学的愿景，并致力于建立一个科学和文化 各式各样的学者和实习生社区围绕着脆弱。这个团队致力于开发下一代 产生所需的科学进步，并将由此产生的战略传播到实践和政策中 将延长老年人的独立性。

Overall: Project Summary This is a renewal application for the Johns Hopkins University Older Americans Independence Center (JHU OAIC). In the current cycle that started in 2013, this OAIC has nurtured extensive accomplishment, contributing to 121 publications and findings that facilitated the funding of 48 additional grants focused on frailty and aging. Investigators in this OAIC seek to promote independence in older adults through the study of the etiologies and clinical ramifications of frailty and through the translation of this knowledge into the development of novel, frailty-focused diagnostic, treatment, and prevention strategies. This proposal seeks to achieve these goals through the following specific aims: 1) Stimulate and develop effective frailty-focused interdisciplinary research programs; 2) Translate the frailty-focused knowledge generated into targeted prevention and treatment strategies that help older adults maintain independence; 3) Provide focused and accessible frailty-related training and mentorship to junior investigators interested in developing careers focused on maintaining independence in older adults; 4) Provide to OAIC-supported investigators the highest quality interdisciplinary expertise and infrastructure in biostatistical, biological, and clinical science as relevant to frailty research; 5) Support the development of innovative methodologies, research strategies and technologies essential to the study of frailty; and 6) Attract outstanding investigators and trainees to frailty research from across the Johns Hopkins University and promote visibility of their science locally and nationally. A Research Education Component (REC) and Pilot Study Core will provide training, mentorship, and both advisory and material support for research projects for supported investigators. Highly integrated resource cores focused on biostatistics, biological mechanisms, and clinical translation and recruitment will provide supported investigators with the interdisciplinary expertise, training, mentorship, assistance, and services necessary to perform outstanding frailty-focused basic, clinical and translational research. A new Information Dissemination Core will extend the reach of findings on frailty developed by the researchers of this OAIC and beyond, through a new website providing navigation and easy access to findings on frailty, innovative educational initiatives, new partnerships with scientific and professional organizations, formation of communities of practice, and outreach efforts. This OAIC will continue to be directed by a long-standing, interdisciplinary, accomplished, and highly visible leadership team who continue to develop an ongoing vision for the next generation of frailty science and have worked to build a scientifically and culturally diverse community of scholars and trainees around frailty. This team is dedicated to developing the next generation of needed scientific advances and disseminating resulting strategies into practice and policy that will extend independence for older adults.