The Administrative Core

摘要 哥伦比亚大学消化和疾病研究中心于2019年成立 在过去15年中，通过基础、翻译和临床的快速增长奠定了基础 研究。CU-DLDRC反映了其成员的热情、合作、生产力和成功 以及哥伦比亚大学对消化系统疾病研究的长期机构支持。CU-DLDRC 由49名高生产率成员(30名正式成员和19名助理成员)组成的互动小组，通过他们的努力团结在一起 在成人和儿童消化系统疾病研究和护理方面的卓越成就。自CU-DLDRC成立以来， 行政核心(AC)通过以下努力加强了合作研究文化：(I) 促进跨学科网络和团队科学，以及基础和临床之间的合作 (2)促进教育、培训、指导和多样性、公平和包容性(Dei)；和(3) 支持新的调查人员。CU-DLDRC的中心研究主题：上皮细胞及其相互作用 消化系统动态平衡与疾病》包含了两个相互关联的主题，对消化系统有重大影响 健康：“上皮细胞动态平衡、新陈代谢和再生”(分主题1)和“上皮细胞之间的相互作用 炎症和癌前病变“(分主题2)。四个生物医学核心提供访问尖端的途径 技术和设施：临床研究和生物医学；有机物和细胞培养；生物成像；以及 生物信息学和单细胞分析。CU-DLDRC包括主动试点和可行性(P/F)和 丰富(EP)计划，赋予下一代科学家权力，促进教育和 智力交流。咨询委员会作为CU-DLDRC的中心组成部分，将有助于校对和 通过优化研究基地的组织来执行其使命、活动和取得成功；财政 管理；协调、评价和不断发展其组成部分；与 监督委员会、NIDDK和其他DDRCC。AC由经验丰富的领导人领导，具有 互补专业：罗伯特·施瓦布医学博士(主任)；蒂莫西·王医学博士和卡拉·马戈利斯医学博士 (副董事)，由AC管理人Seetha Srinivesan，PhD支持。咨询委员会将推动这一使命 CU-DLDRC通过以下具体目标取得成功：通过有效的 行政、预算监督、科学领导和与监督委员会的互动(目标1)。至 确保生物医疗核心(AIM)提供最先进的服务、高效的运营和跨核心协作 2)。通过P/F计划(目标3)提拔下一代科学家并监测他们的成功。扶植 通过研讨会和务虚会提供一个肥沃的环境和知识交流，并通过EP促进Dei (目标4)。在我们的网站(AIM)上突出显示CU-DLDRC、其核心、教育活动和成就 5)。这些目标的成功实现将有助于该中心的效力和成功。

SUMMARY The inception of the Columbia University Digestive and Disease Research Center (CU-DLDRC) in 2019 has its foundational roots over the past 15 years through the resounding growth of basic, translational and clinical research. The CU-DLDRC reflects the enthusiasm, collaborations, productivity and success of its members as well as the long-term institutional support of digestive disease research at Columbia University. The CU-DLDRC comprises an interactive group of 49 highly productive members (30 full and 19 associate), united by their strive for excellence in adult and pediatric digestive disease research and care. Since the CU-DLDRC’s inception, the Administrative Core (AC) has enhanced the collaborative research culture through the following endeavors: (i) Fostering interdisciplinary networks and team science, and collaborations between basic and clinical researchers; (ii) promoting education, training, mentorship and diversity, equity and inclusion (DEI); and (iii) supporting new investigators. The CU-DLDRC’ central research theme “Epithelial Cells and their Interactions in Digestive Homeostasis and Disease” encompasses two interrelated subthemes with major impact on digestive health: “Epithelial Homeostasis, Metabolism and Regeneration” (Subtheme 1) and “Epithelial Interactions in Inflammation and Preneoplasia” (Subtheme 2). Four Biomedical Cores provide access to cutting-edge technologies and facilities: Clinical Research and Biospecimen; Organoid and Cell Culture; Bioimaging; and Bioinformatics and Single Cell Analysis. The CU-DLDRC includes active Pilot and Feasibility (P/F) and Enrichment (EP) Programs, empowering the next generation of scientists and promoting education and intellectual exchange. The AC, as central component of the CU-DLDRC, will contribute to the collation and implementation of its mission, activities and success via optimal organization of the research base; fiscal management; coordination, evaluation and continuous evolution of its components; and communication with oversight committees, the NIDDK and other DDRCCs. The AC is directed by experienced leaders with complementary expertise: Robert Schwabe, MD, PhD (Director); Timothy Wang, MD and Kara Margolis, MD (Associate Directors), supported by AC administrator Seetha Srinivasan, PhD. The AC will promote the mission and success of the CU-DLDRC through these Specific Aims: To provide governance through efficient administration, budgetary oversight, scientific leadership and interactions with oversight committees (Aim 1). To ensure state-of-the-art services, efficient operation and cross-core collaboration by the Biomedical Cores (Aim 2). To promote the next generation of scientists and monitor their success via the P/F Program (Aim 3). To foster a fertile environment and intellectual exchange through seminars and retreats, and to promote DEI via the EP (Aim 4). To highlight the CU-DLDRC, its cores, educational activities and accomplishments on our website (Aim 5). Successful realization of these Aims will contribute to the effectiveness and success of the CU-DLDRC.