MetaOmics

MOSR摘要 Sidney Kimmel癌症中心MetaOmics共享资源(MOSR)的使命是提供 跨SKCC财团的全面资源，满足SKCC成员的所有“组学”需求 通过一个单一的入口。这些“组学”包括：基因组学、表观遗传学、转录组学、蛋白质组学、糖组学、 代谢组学和脂类组学。在上一个项目期间，MOSR通过精心计划的 SKCC以前的癌症基因组共享资源(CGSR)的扩展。CGSR于2007年由 保罗·福蒂纳，医学博士，博士，通过其技术和专门技术促进了前沿癌症研究 基因组学和生物信息学方面的专业知识。响应对范围更广的组学的日益增长的需求 能力，CGSR与德雷克塞尔大学医学院的一个开发设施相结合，由 加思·埃尔利希，FAAAS博士。埃尔利希博士现在担任MOSR主任，Fortina博士担任联席- 合并后的设施的主管。新增或增强的服务包括：咨询教职员工级别的实验 设计服务；涵盖多个组学学科的最先进的实验室服务；以及数据分析 由训练有素的团队提供高吞吐量和高保真的基于组学的技术服务 生物信息学家。除了新的仪器平台外，MOSR继续提供基于Illumina的高性能 吞吐量短读DNA测序和RNAseq功能，以及基于阵列的技术。当前 MOSR的目标包括：1)利用最新的基因组学、蛋白质组学和代谢组学技术 为从事先进癌症研究的SKCC成员提供服务；2)在以下方面提供专业知识和指导 通过单一门户进行实验和项目设计和分析；3)促进用户友好的环境 通过提供专家咨询、以合理的费用提供高质量的服务、快速周转和随时可用 4)对所有样本进行生物信息学分析，确保快速反馈 样本和文库质量，建议未来进行实验，以表明是否需要进行额外的分析；5) 与其他SKCC共享资源协调，特别是生物统计学、翻译病理学和流程 细胞学，代表所有用户高效和有效地支持更大规模的项目。

MOSR Summary The mission of the Sidney Kimmel Cancer Center MetaOmics Shared Resource (MOSR) is to provide a comprehensive resource across the SKCC consortium that meets all the “omics” needs of SKCC members through a single portal. These “omics” include: genomics, epigenetics, transcriptomics, proteomics, glycomics, metabolomics, and lipidomics. The MOSR evolved during the last project period through a carefully planned expansion of the SKCC’s former Cancer Genomics Shared Resource (CGSR). The CGSR, founded in 2007 by Paolo Fortina, MD, PhD, fostered leading-edge cancer research through its technology and specialized expertise in genomics and bioinformatics. In response to growing demand for a broader range of omics capabilities, the CGSR combined with a developing facility at Drexel University College of Medicine, led by Garth Ehrlich, PhD, FAAAS. Dr. Ehrlich now serves as the MOSR Director, and Dr. Fortina serves as Co- Director of the combined facility. New or enhanced services include: consultative faculty-level experimental design services; state-of-the-art laboratory services covering multiple omics disciplines; and data analysis services for high throughput and high fidelity omics-based technologies provided by a team of highly trained bioinformaticians. Besides new instrumentation platforms, the MOSR continues to provide Illumina-based high- throughput short-read DNA sequencing and RNAseq capabilities, as well as array-based technologies. Current goals for the MOSR include: 1) Leverage the latest genomics, proteomics, and metabolomics technologies to serve SKCC members conducting advanced cancer research; 2) Provide expertise and guidance in experimental and project design and analysis through a single portal; 3) Promote a user friendly environment by providing expert consultations, high-quality services at reasonable fees, fast turnaround, and ready access to equipment after training; 4) Provide bioinformatics analysis on all samples ensuring rapid feedback on sample and library quality, suggest future experiments indicating whether additional analyses are warranted; 5) Coordinate with other SKCC Shared Resources, particularly Biostatistics, Translational Pathology, and Flow Cytometry, to efficiently and effectively support larger-scale projects on behalf of all users.