Training in Multi-scale Analysis of Biological Structure and Function

项目摘要 这是​生物结构多尺度分析中NIBIB研究生培训计划的更新 并在加州大学圣地亚哥分校工作。博士前实习生完全从 多尺度生物学专业的正式​跨学科博士学位(接口研究生培训 计划“)，其中包括来自10个排名很高的国内博士项目(生物工程， 生物科学、生物医学、化学和生物化学、机械和航空航天 工程、神经科学和物理学，材料科学和工程、化学工程和 自2015年加入纳米工程公司)。学生在第一年研究生学习结束时提出申请。这款T32 该计划汇集了40名培训教师，并支持了24名来自生物学院的学生 理科(2)、健康科学(9)、工程学(5)和物理科学(8)。它的目标是培养一名新的干部 能够跨越学科边界来解决跨越 从分子到生物体的生物组织。到目前为止，已有44名InterFaces学生毕业。13个是 这款T32的实习生。URM代表增加到29% 培训课程的一个主要特点是七门动手的研究生实验室课程， 向学生介绍在生物尺度上测量和分析生命系统​的先进技术 从分子到整个有机体​的组织。学生使用最先进的设施和 从质谱学到电子显微镜和磁共振成像的技术。科学的 关注生物结构和功能的多尺度分析反映了现代 生物医学发展和应用新的定量方法，从物理，工程， 从生物科学和健康科学到生物医学的综合问题。经常方案活动，包括 每两周一次的毕业生研讨会、年度研讨会和务虚会、课程开放参观和季度课程 会议，促进来自不同学科的学生和教师之间的互动。双师型 培训计划成功地促进了重要领域的新的跨学科合作，包括 发展生物学、神经科学和癌症、心血管疾病、诊断学和药物发现。 这份续签申请建议继续培养最多元化的学生群体，使其成为 结构一体化的多尺度生物功能分析。它将开发一门新的数据实验课程 多尺度生物学科学，为学员创建一个新的校友导师网络，并建立一个结构化的 共同指导未来学生的跨学科研究轮换。

Project Summary This is a renewal of an NIBIB Graduate Training Program in ​Multi-Scale Analysis of Biological Structure and Function at the University of California San Diego. Pre-doctoral trainees are drawn exclusively from a formal ​Interdisciplinary Ph.D. specialization in Multi-Scale Biology (the “Interfaces Graduate Training Program”), which includes students from 10 highly ranked participating home Ph.D. programs (Bioengineering, Biological Sciences, Biomedical Sciences, Chemistry and Biochemistry, Mechanical and Aerospace Engineering, Neurosciences and Physics, with Materials Science & Engineering, Chemical Engineering and Nanoengineering joining since 2015). Students apply at the end of their first year of graduate studies. This T32 program brings together 40 training faculty and supported 24 students in the current period are from Biological Sciences (2), Health Sciences (9), Engineering (5) and Physical Sciences (8). It’s goal is to train a new cadre of scientist who can cross disciplinary boundaries to solve important biomedical problem that span scales of biological organization from molecule to organism. To date 44 Interfaces students have graduated. 13 were trainees on this T32. URM representation increased to 29% A central feature of the training curriculum is seven hands-on graduate laboratory courses that introduce students to advanced techniques for measuring and analyzing living systems ​at scales of biological organization spanning from molecule to whole organism​. Students use state-of-the-art facilities and technologies from mass spectrometry to electron microscopy and magnetic resonance imaging. The scientific focus on multi-scale analysis of biological structure and function reflects a fundamental challenge of modern biomedical science in developing and applying novel quantitative approaches from the physical, engineering, biological and health sciences to integrative problems in biomedicine. Regular program activities, including bi-weekly graduate seminars, annual symposia and retreats, course open houses and quarterly program meetings, promote interactions between students and faculty from different disciplines. The dual-mentored training program is successful in promoting new interdisciplinary collaborations in important areas including developmental biology, neuroscience and cancer, cardiovascular disease, diagnostics and drug discovery. This renewal application proposes to continue to train the most diverse student body to be effective leaders in structurally integrated multi-scale analysis of biological function. It will develop a new lab course in Data Sciences for Multiscale Biology, create a new Alumni Mentor Network for trainees and a structured co-mentored interdisciplinary research rotation for prospective students.