Research Support Core

项目摘要：研究支持核心 我们在P50卓越研究中心的背景下提出了一个研究支持核心(RSC)： 翻译与预防科学中心(CTAPS)皇家莎士比亚委员会的首要目标是促进一项新的 一代又一代的研究集中在(A)应激诱导的大脑免疫信号的变化，从而产生 易受物质滥用和心脏代谢性疾病的影响，(B)确定延展性保护 可预防或减轻压力的下游健康后果的过程，以及(C) 为非裔美国人制定预防药物滥用和心脏代谢的干预措施 疾病。为此，研究支助核心(RSC)将：(A)监督和执行以下分析 中心研究项目收集的神经认知、炎症、心脏代谢和生物统计数据 (B)就设计方案向中心科学家提供智力咨询， 有希望的研究和干预目标，以及对结果的解释；和(C)赞助教育和 为CTAPS科学家和更广泛的科学界提供培训经验。这一核心代表着 继续佐治亚大学科学家和美国科学家之间富有成效的合作 西北大学，他们共同建立了产生煽动性的管道， 与非裔美国人的物质使用和整体健康相关的心脏代谢和神经成像数据。这个 RSC包括大量的智力资本和用于神经成像分析的最先进的科学设施 数据和分析炎症和心脏代谢功能的生物标志物。它由三个部分组成 次级评分：神经认知(NCO)、炎症(INF)和生物统计学(BSC)。RSC的目标是：(1) 为RP主管、跨学科工作组和试点项目调查人员提供智力咨询； (2)帮助制定收集高质量神经成像、炎症和心脏代谢数据的方案；(3) 测定炎症和心脏代谢生物标志物的生物标记物，(4)处理和分析收集的数据 和(5)为CTAPS的科学家、学员和 分支机构，以及通过在线提供教育为科学界提供资源 研讨会和会前讲习班。

PROJECT SUMMARY: Research Support Core We propose a Research Support Core (RSC) in the context of a P50 Research Center of Excellence: The Center for Translational and Prevention Science (CTAPS). The RSC’s overarching goal is to facilitate a new generation of research focused on (a) stress-induced alterations in brain-immune signaling that create vulnerabilities to substance misuse and cardiometabolic disease, (b) the identification of malleable protective processes that can prevent or mitigate the downstream health consequences of stress, and (c) the development of interventions for African Americans that prevent substance misuse and cardiometabolic disease. To this end, the Research Support Core (RSC) will: (a) oversee and execute analyses of neurocognitive, inflammatory, cardiometabolic, and biostatistical data collected by Center Research Projects (RPs) and Pilot Studies; (b) provide intellectual consultation to Center scientists regarding design protocols, promising targets for research and intervention, and interpretation of results; and (c) sponsor educational and training experiences for CTAPS scientists and the broader scientific community. This Core represents a continuation of a highly productive collaboration between scientists at the University of Georgia and Northwestern University, who together have established pipelines for generating inflammatory, cardiometabolic, and neuroimaging data relevant to African Americans’ substance use and overall health. The RSC comprises substantial intellectual capital and state-of-the science facilities for analysis of neuroimaging data and assaying biomarkers of inflammatory and cardiometabolic functioning. It is composed of three subscores: Neurocognitive (NCO), Inflammatory (INF), and Biostatistical (BSC). The RSC’s aims are to: (1) provide intellectual consultation to RP directors, transdisciplinary work groups, and pilot project investigators, (2) help develop protocols for collecting high-quality neuroimaging, inflammatory, and cardiometabolic data, (3) assay biospecimens for inflammatory and cardiometabolic biomarkers, (4) process and analyze data collected in neuroimaging paradigms, and (5) provide educational experiences to CTAPS scientists, mentees, and affiliates, as well as serving as a resource for the scientific community by providing education through online seminars and preconference workshops.