Eradicating bacterial biofilms with nitroxide-antimicrobial hybrids

该项目旨在开发新的抗菌剂，以解决耐药性感染和称为生物膜的弹性细菌群落的增加。我们的目标是在我们的抗菌机制的基础知识中开辟新天地，并通过融合细胞/分子微生物学和合成化学方法来利用这种理解。我们试图深入了解氮氧化物如何诱导细菌生物膜分散，这对于发现不会因耐药性发展而失败的抗生物膜分子至关重要。这些突破应该会导致我们在从医学和兽医到生物技术和农业等领域减少生物膜相关感染发生的能力发生重大变化。

This project aims to develop new antimicrobials to address the rise of drug-resistant infections and resilient bacterial communities called biofilms. We aim to break new ground in our fundamental knowledge of antimicrobial mechanisms and exploit this understanding by fusing cellular/molecular microbiology and synthetic chemistry approaches. We seek to gain an in-depth understanding of how nitroxides induce bacterial biofilm dispersal, which is critical for the discovery of anti-biofilm molecules that do not fail due to resistance development. These breakthroughs should induce a step-change in our ability to reduce the occurrence of biofilm-related infection in fields ranging from medical and veterinary to biotechnology and agriculture.