Integrative Training in Oncogenic Signaling

项目总结/摘要 这第一次更新申请寻求继续国家癌症研究所（NCI）的支持，以成功的“综合” 致癌信号的培训”（ITOS）计划开发，由一组精选的博士后研究员 南卡罗来纳州医科大学霍林斯癌症中心（HCC）的癌症科学家 （MUSC）。该计划发生在一个活跃和不断发展的医疗中心与国家的最先进的设施，一个充满活力 NCI指定的癌症中心，和博士后事务的活跃办公室。由项目主管团队领导 ITOS计划拥有非常强大的癌症研究和领导背景， 支持将受训人员安置在由该计划领导的经验丰富、资金充足、富有成效的实验室 教师谁居住在一个互动的，多部门的研究环境与广泛的资源。每个 学员有一名初级导师和一名/两名具有互补专业知识的次级导师，以确保 和有价值的观点，提高整体癌症相关的研究培训经验。目标 ITOS计划的内容保持不变，旨在提供积极的指导、监督和研究培训 在尖端的方法;发展有用的学术和基本的职业发展技能;以促进 与教师和其他学员的协作，跨学科的互动;以及，提供接触到当前 癌症研究发现以及这些发现如何被转化为预防，诊断， 治疗癌症ITOS计划有七个基本的计划组成部分：1）33个成员计划 教师分享共同的癌症研究兴趣，并为学员提供必要的指导; 2）一个 在指定的计划学院实验室工作两年的经验; 3）ITOS计划研究俱乐部， 一个吸引人的社区论坛，供学员和项目教师讨论正在进行的工作以及 最新发现; 4）共享研究资源研讨会和尖端生物技术的量身定制培训; 5)在人道主义协调委员会主办的专题研究务虚会、专题讨论会、 6）职业发展讲习班和课程，使受训者具备以下能力： 独立的成功;和，7）在至少两次专业会议上建立全国网络的机会 每年.在其第四年，ITOS计划已毕业9研究员; 1 MD，1 MD/博士，7博士。的受训人员 不同的背景，58%的女性和30.8%的代表性不足的种族/少数民族，他们都有 成功地过渡到学术界或工业界的职位。根据能力，容量，轨迹， MUSC为癌症相关培训提供的资金，以及在最初供资期间取得的成功， ITOS计划要求每年为7名博士后培训人员提供支持，这意味着 两个实习生职位。总之，我们的ITOS计划只提供独特的经验和机会， 提供给选定的ITOS研究员，该计划，由一个优秀的干部计划教师领导， 预计对当地和全国新出现的初级调查员仍然具有很大的吸引力。

PROJECT SUMMARY/ABSTRACT This first renewal application seeks continued National Cancer Institute (NCI) support for a successful ‘Integrative Training in Oncogenic Signaling’ (ITOS) Program developed to train postdoctoral fellows by a select group of cancer scientists affiliated with the Hollings Cancer Center (HCC) at the Medical University of South Carolina (MUSC). The programtakes place in an active and growing medical center with state -of-the-art facilities,a vibrant NCI-designated cancer center, and an active Office of Postdoctoral Affairs. Led by a Program Directorship team with an exceptionally strong cancer research and leadership background, the ITOS Program selects and supports the placement of trainees in experienced, well-funded, productive laboratories led by the Program Faculty who reside in an interactive, multi-departmental research environment with extensive resources. Each trainee has a primary mentor and one/two secondary mentors with complementary expertise to ensure distinct and valuable perspectives that enhances the overall cancer-relatedresearch training experience. The objectives of the ITOS Programremain unchanged, seeking to provideproactive mentoring, oversight and research training in cutting-edge methodology; to develop useful academic and essential career development skills; to foster collaborative, interdisciplinary interactions with faculty and other trainees; and, to provide exposure to current cancer research discoveries and how these are being translated into novel approaches to prevent, diagnosis, and treat cancer. The ITOS Program has seven essential programmatic components: 1) 33 member Program Faculty who share common cancer research interests and provide essential mentoring for trainees; 2) one to two year experiences in designated Program Faculty laboratories; 3) an ITOS Program Research Club providing an engaging community forum for the trainees and Program Faculty to discuss work in progress as well as the latest discoveries; 4) shared research resource workshops and tailored training in cutting-edge biotechnologies; 5) interdisciplinary engagement with trainees in HCC-sponsored thematic research retreats, symposia, work in progress meetings, and seminars; 6) career development workshops and courses that equip trainees for independent success; and, 7) opportunities to network nationally at a minimum of two professional conferences each year. In its fourth year, the ITOS Program has graduated 9 fellows; 1MD, 1MD/PhD, 7 PhDs. Trainees from diverse backgrounds, 58% female and 30.8% underrepresented racial/ethnic minorities, whom have all successfully transitioned to positions in academia or industry. Based on the capabilities, capacity, trajectory of MUSC for cancer-related training, and the successful accomplishments achieved during its initial funding period, the ITOS Program is requesting the support for seven postdoctoral trainees each year, representing an increase of two trainee positions. In summary, our ITOS Program offers distinct experiences and opportunities only afforded to the selected ITOS Fellows, and the program, led by an outstanding cadre of Program Faculty, is anticipated to remain highly attractive to emerging junior investigators locally and nationally.