Sustainable Bioproduction of Lactobionic Acid from Whey-Based Bioprocess and Expansion of Accessible Markets through Biotech Active Ingredients ("BIONICe")

该项目的重点是利用真正的工业废物流，或从中衍生的低价值产品的生物增值。例如，乳清、乳清渗透物或乳清衍生乳糖的生物增值，尽管每年在奶酪和其他乳制品生产中产生1.8亿至1.9亿吨乳清，但这些乳糖仍然是开发不足的自然资源。该项目的重点是加速开发以乳清为基础的可持续生物工艺，用于生产乳糖酸，这是一个关键，高效率和理想的抗衰老和保湿化妆品成分，也可应用于一系列其他不同的市场，如食品/制药和化学工业。该项目的成果将是一个商业相关的目的-Activatec致力于对环境敏感的化妆品和个人护理原料的生产，特别是护肤品原料的生产，使Activatec能够充分利用化妆品行业不断变化的面貌，这是由快速变化的消费趋势所驱动的，“有机”、“天然”、“绿色”和“对环境敏感”的产品标签以及对“发酵化妆品”的兴趣趋势生产方法过于简单，与报道的非商业方法一致，但设计创新，将允许成功的商业开发。整个方法旨在实现可持续发展，采用环保的制造方法，包括下游产品回收和纯化所需的方法。预计该技术还将具有灵活性，有可能交叉应用于其他相关特定目标产品和衍生物的生产。

The project is focused on the use of true industrial waste streams, or the bio valorisation of low-value products derived from them. One example would be bio valorisation of whey, whey permeate, or whey derived lactose, which although produced in 180 to 190 million tonnes per annum from the manufacture of cheese and other dairy products, are still poorly exploited natural resources.The focus of this project is an accelerated development of a whey-based, sustainable bioprocess for the manufacture of lactobionic acid, a key, highly efficacious and desirable anti-ageing and moisturising cosmetic ingredient which also has applications in a range of other diverse markets such as Food/Pharma and the chemical industry. The project outcome will be a commercially relevant end-to­ end process ready for first tech transfer and initial manufacturing trials at a selected Toll manufacturing company.Targeting the environmentally sensitive manufacture of ingredients primarily for use in cosmetics and personal care and in particular for use in skincare permits Activatec to fully exploit the changing face of the cosmetics industry driven by the rapidly changing consumer trends towards 'organic'; 'natural' 'green' and 'environmentally sensitive' product labelling and the trending interest in 'fermented cosmetics'The manufacturing approach is simplistic, in line with reported non-commercial methods, but innovative in design which will permit successful commercial exploitation. The whole approach is designed for sustainability utilising environmentally benign manufacturing methods including those required for the downstream recovery and purification of the product. The technology is also expected to be flexible with the potential for cross-application for the manufacture of other related specific target products and derivatives.