Comparison of Hemorrhagic & Ischemic Stroke Among Blacks and Whites

项目总结： 我们寻求继续我们以人群为基础的中风发病率和病死率、风险流行率的研究。 1,368,604人的混血大都市人口中的因素、卒中治疗和卒中后结局 其中223,417人(16.3%)是黑人(美国2010年人口普查)。我们预计将确认约4500名医生确认 和特征明确的卒中事件(预计2900个缺血性卒中，525个出血性卒中，1075个 短暂性脑缺血发作[TIA])在大辛辛那提/北肯塔基州五个县的居民中 2019年7月1日至2020年12月31日期间所有20家区域医院/急诊室的(GCNK)区域，以及2,000份调查 参与者。 近25年来，我们一直在研究中风发病率和病例死亡率的趋势，并证明了 种族差异，非洲裔美国人的中风发病率是白人的两倍以上。在每个先前的 在研究期间，我们还通过人群检查了危险因素(以及对中风的知识)的流行率 调查，以便将我们的时间趋势调查结果放在背景中。 除了继续这些重要的活动外，我们还研究了中风复发的人群- 基于我们之前研究期间的时尚，发现黑人比其他人更有可能复发 白色的。我们现在寻求评估复发率的时间趋势，特别是 那些暂时的趋势。在此之前，我们已经试行了获得基于总体的结果的方法 中风患者，我们现在已经准备好在我们整个人口中获得缺血性中风后的结果， 现场迫切需要的数据。最后，我们已经使用我们的数据来通知中风的资格 通过与NIH StrokeNet的密切合作进行临床试验，并与科学界共享了我们的数据 社区为此目的。通过获得更详细的结果数据，我们现在将能够更好地了解 拟议的恢复和预防试验也是如此。

PROJECT SUMMARY: We seek to continue our population-based study of stroke incidence and case fatality, prevalence of risk factors, stroke treatment, and post-stroke outcomes within a biracial metropolitan population of 1,368,604 of whom 223,417 (16.3%) are of black race (US Census 2010). We expect to identify ~4500 physician confirmed and well characterized stroke events (projected 2900 ischemic strokes, 525 hemorrhagic strokes, and 1075 transient ischemic attack [TIA]) among residents of the five-county Greater Cincinnati/Northern Kentucky (GCNK) region at all 20 regional hospitals/EDs for the period 7/1/2019 to 12/31/2020, as well as 2,000 survey participants. For almost 25 years, we have studied trends in stroke incidence and case fatality and have demonstrated a racial disparity where stroke incidence in African-Americans is more than double that of whites. In each prior study period, we have also examined the prevalence of risk factors (and knowledge of stroke) via a population survey in order to put our temporal trend findings into context. In addition to continuing these important activities, we also examined stroke recurrence in a population- based fashion in our prior study period, finding that blacks were more likely to have recurrent events than whites. We now seek to evaluate temporal trends in recurrence rates, and specifically racial disparities in those temporal trends. Previously we had piloted methods of obtaining a population-based outcome among stroke patients, and we are now ready to obtain outcomes after ischemic stroke across our entire population, data that are desperately needed in the field. Finally, we have used our data to inform eligibility for stroke clinical trials via a close collaboration with NIH StrokeNet and have shared our data with the scientific community for this purpose. By obtaining more detailed outcomes data, we will now be able to better inform proposed recovery and prevention trials as well.