Cellular and Synaptic Hypothalamic Reorganization After Exercise Training

体力活动提供多种新陈代谢益处，包括改善胰岛素敏感性和身体状况 组成。在大脑内部，人们对运动对突触/细胞的剧烈改变的影响知之甚少 这些特性以及这些效应如何导致新陈代谢改变。在目前的提案中，我们发现 中枢神经系统来源的GLP-1神经元在运动中被激活。此外，GLP-1和GLP-1的模拟 模仿运动对弓状黑素皮质素神经元的影响。总的来说，这些数据支持这一假设 运动后激活NTS GLP-1弓形POMC环路。我们将识别手机 运动激活GLP-1和黑素皮质素神经元的机制。我们还将确定一个角色 这些急慢性细胞机制来调节新陈代谢。

Physical activity provides multiple metabolic benefits, including improved insulin sensitivity and body composition. Within the brain, less is known about the effects of exercise to acutely alter synaptic/cellular properties and how these effects contribute to altered metabolism. In the current proposal, we have found that CNS derived GLP-1 neurons are activated in response to exercise. Moreover, GLP-1 and GLP-1 mimetics mimic the effects of exercise on arcuate melanocortin neurons. Collectively, these data support the hypothesis that an NTS GLP-1 to arcuate POMC circuit is activated in response to exercise. We will identify cellular mechanisms through which exercise activates GLP-1 and melanocortin neurons. We will also determine a role for these acute/chronic cellular mechanisms to regulate metabolism.