Metal-catalyzed transformations of unsaturated compounds

项目总结 有机分子在许多与人类健康相关的研究领域发挥着重要作用， 包括生物学、医学和药物开发。合成有机食品的目标之一 化学是通过提供对有机分子的访问来促进这些领域的发现 增加复杂性和多样性，并通过扩展我们的能力来有效地操纵其 结构及其属性。为实现这一目标所作努力的一个关键部分是发展 新的有机转变。这项提案中描述的研究目标是 两类新反应的发展：1)末端炔烃的反选择性氢烷基化反应。 2)炔烃的差异二氢官能化反应。一旦成功开发，这些 转型将极大地增加产品的复杂性和多功能性， 直接从炔烃中提取。考虑到炔烃作为反应中间体的重要性 有机化学，这将对生物相关的合成产生重大影响 化合物。

Project summary Organic molecules play an important role in a number of research areas relevant to human health, including biology, medicine, and drug development. One of the goals of synthetic organic chemistry is to facilitate discovery in these fields by providing access to organic molecules of increasing complexity and variety, and by expanding our ability to efficiently manipulate their structure and their properties. A critical part of the efforts toward this goal is the development of new organic transformations. The goal of the research described in this proposal is the development of two new classes of reactions: 1) anti-selective hydroalkylation of terminal alkynes. 2) Differential dihydrofunctionalization of alkynes. Once successfully developed, these transformations will greatly increase the complexity and versatility of products that can be obtained directly from alkynes. Considering the importance of alkynes as reactive intermediate in organic chemistry, this will have significant impact on the synthesis of biologically relevant compounds.