Project-Pilots

这个提议的Roybal中心的试点核心的中心目标是启动和完成NIH阶段0-III 使中心研究人员能够为IV-V期有效性竞争独立资金的研究， 实施干预试验，以改善痴呆症患者（PWD）的姑息治疗， 服务和支持（LTSS）设施。为了实现其选择和支持试点项目的主要目标， 将行为经济学和数据科学的思想转化为改善居住在美国的PWD护理 指导委员会将每年向所有附属机构发出申请 调查员及其受训人员。试点核心PI Jason Karlawish（医学博士）和其他委员会成员将对 每个应用程序的七个标准，并分配每个使用9点NIH量表的总分。的 然后，委员会将向（1）罗伊巴尔中心的 咨询委员会;（2）Genesis HealthCare领导层（针对Genesis内部提出研究的项目 设施）;和（3）NIA官员和Roybal协调中心。 试点核心有三个其他具体目标。首先，我们的目标是指导初级教师和博士后研究员， 开发和测试行为改变干预措施。多名指导委员会成员和 附属调查员是领先的行为研究导师，并已承诺的大部分， 他们的职业生涯到导师。我们预计初级调查员将在至少一半的试点中发挥突出作用 通过该中心支持的项目，并将利用该中心的年度研讨会推出新的指导 初级和高级调查员之间的关系。第二，我们的目标是促进 中心的附属研究人员，特别是通过联系那些在0-III期行为干预的专业知识 与拥有行为经济学，数据科学， 定性方法、统计学和实施科学。这些行为科学家之间的合作 和方法学家将使我们能够制定可扩展的干预措施，可衡量地改善结果。 第三，试点核心将为所有Roybal提供集中的数据和安全监测计划和监督。 中心飞行员。Pilot Core PI Karlawish和Overall PI Halpern都是研究伦理方面的专家。在 与中心经验丰富的高级工作人员一起，他们将开发数据和安全监测 所有试点项目的计划作为中心的共享资源。该试点核心提出了第一阶段和第0阶段 第一年的资助项目，并详细介绍了这些项目。这两个试点项目被选中 在准备该中心提案的初步申请之后。尽管这一最初的呼吁 在一个简短的时间轴上，提交了许多特殊的申请。因此，我们还提供了简短的 说明将在今后几年考虑供资的其他四项示范性提案。

The central goal of the Pilot Core of this proposed Roybal Center is to launch and complete NIH Stage 0-III studies that position Center investigators to compete for independent funding for Stage IV-V effectiveness and implementation trials of interventions to improve palliative care for persons with dementia (PWD) in long-term services and support (LTSS) facilities. To achieve its primary goal of selecting and supporting pilot projects that translate ideas from behavioral economics and data science into improvements in care for PWD residing in LTSS facilities, the Steering Committee will issue an annual request for applications to all Affiliated Investigators and their trainees. Pilot Core PI Jason Karlawish, MD and other Committee members will rate each application on seven criteria and assign each an overall score using the 9-point NIH scale. The Committee will then propose the highest-scored pilots for final funding decisions to (1) the Roybal Center's Advisory Committee; (2) the Genesis HealthCare leadership (for projects proposing studies within Genesis facilities); and (3) NIA officials and the Roybal Coordinating Center. The Pilot Core has three other specific aims. First, we aim to mentor junior faculty and post-doctoral fellows in developing and testing behavior change interventions. Several Steering Committee members and numerous Affiliated Investigators are leading behavioral research mentors, and have committed substantial portions of their careers to mentorship. We expect junior investigators to feature prominently in at least half of the pilot projects supported through this Center, and will use the Center's annual Symposium to launch new mentoring relationships among junior and senior investigators. Second, we aim to foster new collaborations among the Center's Affiliated Investigators, particularly by linking those with expertise in Stage 0-III behavioral intervention research with investigators who possess methodological expertise in behavioral economics, data science, qualitative methods, statistics, and implementation science. These collaborations between behavioral scientists and methodologists will enable us to develop scalable interventions that measurably improve outcomes. Third, the Pilot Core will provide centralized data and safety monitoring plans and oversight for all Roybal Center pilots. Pilot Core PI Karlawish and Overall PI Halpern are both experts in research ethics. In conjunction with the Center's highly experienced senior staff, they will develop data and safety monitoring plans for all pilot projects as a shared resource of the Center. This pilot core proposes a Stage I and a Stage 0 project for funding in year 1, and describes these projects in detail. These two pilot projects were selected following an initial call for applications in preparation of this Center proposal. Although this initial call operated on an abridged timeline, many exceptional applications were submitted. We therefore also provide brief descriptions of four other exemplary proposals that will be considered for funding in future years.