Biomechanics Core

虽然肌肉骨骼组织具有多种生物学作用，但其主要功能是提供 机械支持，使日常生活的活动。受伤、衰老、退化或疾病， 肌肉骨骼组织可能会经历机械功能的下降，这种功能的丧失可以 起源于不同的长度尺度具有发育、生长和治疗性治疗、机械功能 可以在这些相同的长度尺度上改善和改变。因此，必须评估 肌肉骨骼组织力学是肌肉骨骼的基础和转化研究的主要焦点 组织形成、发育、退化和治疗。此外， 生物力学量化必须继续发展的步伐与不断深化的机械 肌肉骨骼组织分子生物学和生理学知识， 成像技术，并与新的治疗发展，以辨别功能的结果， 这些研究。生物力学核心（BC）的总体目标是开发和提供广泛的 一系列标准和创新的生物力学方法来评估肌肉骨骼组织 在发育、疾病、损伤和修复的背景下， 培训和资助利用这些分析的新项目和合作。 在上一个资助周期中，宾夕法尼亚大学肌肉骨骼中心的生物力学核心（BC） 疾病（PCMD）已发展成为一个蓬勃发展的资源，为肌肉骨骼研究界在 宾夕法尼亚大学和费城地区及邻近各州。在这次更新申请中， 我们将进一步扩大服务，以满足对专业技术的需求，并开发新的 和创新的方法，解决肌肉骨骼组织的多尺度力学。BC将 继续在Robert Mauck博士（自2011年起担任BC主任）的指导下运作，沿着捐款 Snehal Shetye博士（自2015年起担任BC技术总监）的支持。我们的目标是提供 指导和培训（目标1），为生物力学测定提供专业知识和服务（目标2）， 创新的生物力学测试技术（目标3），并为开发新的， 探索性项目和合作（目标4）。成功实现这些目标将大大提高 宾夕法尼亚大学的环境和研究人员的能力以及区域研究 社区，导致新的方法来解决肌肉骨骼疾病的长度尺度和 鼓励现有和新的PCMD成员之间的新合作，这些成员以前没有包括 在他们的肌肉骨骼研究项目中进行生物力学功能分析。

While musculoskeletal tissues have multiple biological roles, their primary function is to provide mechanical support to enable the activities of daily living. With injury, aging, degeneration, or disease, musculoskeletal tissues may experience a decline in mechanical function, and this loss of function can originate at different length scales. With development, growth, and therapeutic treatment, mechanical function can improve and change across these same length scales. As such, it is essential that assessment of musculoskeletal tissue mechanics be a primary focus in both basic and translational studies of musculoskeletal tissue formation, development, degeneration, and treatment. Moreover, the innovation and sophistication of biomechanical quantification must continue to develop at a pace on par with the ever-deepening mechanistic knowledge of musculoskeletal tissue molecular biology and physiology, with advances in molecular and imaging technologies, and with new therapeutic developments in order to discern the functional outcomes in these studies. The overall objective of the Biomechanics Core (BC) is to to develop and provide a wide range of standard and innovative biomechanical approaches to evaluate musculoskeletal tissue function across length scales in the context of development, disease, injury and repair, and to provide training and funding for new projects and collaborations utilizing these assays. Over the last funding cycle, the Biomechanics Core (BC) at the Penn Center for Musculoskeletal Disorders (PCMD) has developed into a thriving resource for the musculoskeletal research community at the University of Pennsylvania and in the Philadelphia region and neighboring states. In this renewal application, we will further expand our services to meet the increased demand for specialized techniques and develop new and innovative methods that address the multi-scale mechanics of musculoskeletal tissues. The BC will continue to operate under the direction of Dr. Robert Mauck (BC Director since 2011), along with contributions and support from Dr. Snehal Shetye (BC Technical Director since 2015). Our Specific Aims are to provide guidance and training (Aim 1), to provide expertise and service for biomechanical assays (Aim 2), to develop innovative biomechanical testing techniques (Aim 3), and to provide funding for the development of novel, explorative projects and collaborations (Aim 4). Successful completion of these Aims will significantly enhance the environment and the capabilities of researchers at the University of Pennsylvania and the regional research community, leading to new approaches to address musculoskeletal disorders across length scales and stimulating new collaborations between current and new PCMD members who have not previously included analysis of biomechanical function in their musculoskeletal research programs.