Patient-Centred, Biomechanics-Based Customisation for Improved Treatment of Corneal Conditions

** 项目目标：** 我们的项目引入了角膜治疗的范式转变，提供前所未有的定制化和精确度。我们计划利用创新技术进行体内角膜生物力学，地形图和微观结构映射（doi：10.3389/fbioe.2019.00105，doi：10.1098/rsif.2020.0900，doi：10.1098/rsif.2018.0685）。我们的方法集成了软件工具，这些软件工具可以解释患者特定的角膜生物力学和地形图，并了解其组织微观结构（控制生物力学特性的分布并反映其在疾病中的恶化）。这些工具将包含在代表性和临床验证的数字眼睛模型上训练的AI神经网络及其与治疗程序的相互作用。在该项目中，这些用户友好的工具将过渡到临床应用，通过临床试验进行验证，并为监管部门的批准和商业化做好准备。项目重点：** 该项目针对四种不同的角膜治疗方法：1）我们将开发用于阻止圆锥角膜进展的交联程序的定制方法。2）我们将开创角膜内环段手术的个性化策略，以恢复严重扭曲的角膜的健康角膜几何形状。3）此外，我们将改进角膜塑形镜的验配，以矫正近视并减缓其进展。（doi：10.1097/ICL.00000000000190）. 4）为了有效地管理散光，我们将创建一种个性化的方法来计划白内障手术中的角膜缘切口。采用数值模拟和人工智能的初步研究已经成功地降低了这四个领域的风险，使该项目能够专注于开发、验证和优化临床和商业治疗工具。**团队组成：** 我们的联盟由在相关领域拥有深厚专业知识的杰出合作伙伴组成。他们在数值建模、体内眼部生物力学表征、离体力学测试、眼部微观结构分析、多尺度数值建模、角膜健康、角膜地形图测量、手术治疗和临床实践方面提供了强大的背景（doi：10.1080/02713683.2022.2154807，doi：10.1016/j.medntd.2022.100133）。他们的综合知识和协同作用使该联盟能够在关键治疗中开发、验证和实施定制方法。技术开发将由Ocuwell Limited和普利茅斯大学团队负责，而延世大学、牙山医疗中心和Eyereum眼科诊所的合作伙伴将进行临床开发和验证。通过利用所有合作伙伴广泛的跟踪记录和专业知识，该项目将取得成功，确保有效的项目管理，并实现其临床和商业目标。

**Project's objectives:**Our project introduces a paradigm shift in corneal treatments, offering unprecedented customisation and precision. We plan to leverage innovative technologies for in-vivo corneal biomechanics, topography, and microstructure mapping (doi:10.3389/fbioe.2019.00105, doi:10.1098/rsif.2020.0900, doi:10.1098/rsif.2018.0685). Our approach integrates software tools that account for patient-specific corneal biomechanics and topography and understanding of their tissue microstructure (which controls distribution of biomechanical properties and reflects their deterioration in disease). These tools will incorporate AI neural networks trained on representative and clinically validated numerical eye models and their interactions with treatment procedures. In this project, these user-friendly tools will transition into clinical applications, undergo validation through clinical trials, and be prepared for regulatory approvals and commercialisation.**Project Emphasis:**The project targets four distinct corneal treatments:1) We will develop customisation methods for cross-linking procedures to arrest keratoconus progression.2) We will pioneer personalised strategies for intracorneal ring segment surgeries to restore healthy corneal geometry in significantly distorted corneas.3) Moreover, we will refine the fitting of orthokeratology contact lenses to correct myopia and slow its progression (doi:10.1097/ICL.0000000000000190).4) To manage astigmatism effectively, we will create a personalised approach to plan limbal incisions in cataract surgeries.Preliminary studies employing numerical simulation and AI have successfully de-risked these four areas, allowing the project to concentrate on developing, validating, and optimising clinical and commercial treatment tools.**Team Composition:**Our consortium consists of distinguished partners with profound expertise across relevant areas. They provide robust backgrounds in numerical modelling, in-vivo ocular biomechanics characterisation, ex-vivo mechanical testing, ocular microstructure analysis, multi-scale numerical modelling, corneal health, corneal topography measurement, surgical treatments, and clinical practice (doi:10.1080/02713683.2022.2154807, doi:10.1016/j.medntd.2022.100133). Their combined knowledge and collaborative synergy equip the consortium to develop, validate, and implement customisation methods across key treatments.The technology developments will be undertaken by Ocuwell Limited and the University of Plymouth teams, while partners at Yonsei University, Asan Medical Centre, and Eyereum eye clinic will conduct the clinical development and validation. By utilising all partners' extensive track records and expertise, the project is positioned for success, ensuring efficient project management, and achieving its clinical and commercial objectives.