P30 Center Core Grant for Vision Research

摘要 眼免疫生物学核心 视觉研究需要识别和量化细胞类型及其效应分子，以 探讨视觉发育和退化的机制及致盲感染的发病机制 和炎症，以及挽救视力的疗法的疗效。新的眼免疫生物学核心(OIC) 在俄克拉荷马大学健康科学中心负责为视觉研究人员提供 用于检查视觉发育模型中涉及的单个细胞的最先进的仪器， 在细胞和分子水平上的退化、感染和炎症。此核心支持VISION OUHSC的16个NEI资助的R01赠款和其他与视觉相关的项目的研究，位于院长 麦基眼科研究所。我们预计将有40多种眼病模型由Cytek Aurora进行分析 和BioPlex 200多路悬浮阵列。我们的系统分析员在培训人员方面非常熟练， 协助实验和数据分析，维护核心设备达到质量标准。因此， OIC提供处于流式细胞术前沿的仪器和专业知识。重要的是，我们计划 继续扩展这一核心以保持领先地位，使视觉研究人员继续 具有竞争力，并保持高质量的研究。这一新颖和创新的核心是激励和 致力于为所有愿景提供有效、高效、用户友好和高质量的研究环境 俄亥俄州立大学的研究人员。

ABSTRACT Ocular Immunobiology Core Vision research requires the identification and quantification of cell types and their effector molecules to investigate the mechanisms of visual development and degeneration, the pathogenesis of blinding infection and inflammation, and the efficacy of vision-saving therapeutics. The new Ocular Immunobiology Core (OIC) at the University of Oklahoma Health Sciences Center is responsible for providing vision researchers with state-of-the-art instrumentation for examining single cells involved in vision models of development, degeneration, infection, and inflammation at the cellular and molecular levels. This Core supports vision research on 16 NEI-funded R01 grants and other vision-related projects at OUHSC, and is located in the Dean McGee Eye Institute. We anticipate more than 40 ocular disease models to be analyzed by the Cytek Aurora and BioPlex 200 Multiplex Suspension Array. Our Systems Analyst is highly skilled in training personnel, assisting with experiments and data analysis, and maintaining core equipment to a quality standard. As such, the OIC provides instrumentation and expertise that is at the forefront of flow cytometry. Importantly, we plan to continue to expand this core to remain ahead of the curve allowing vision researchers to continue to be competitive and maintain a high quality of research. This novel and innovative Core is motivated and committed to providing an effective, efficient, user-friendly, and high-quality research environment for all vision researchers at OUHSC.