Accessible Innovative Methods for the Safety and Sustainability Assessment of Chemicals and Materials

CHIASMA的核心目标是为下一代化学品和材料的危害和风险评估开发一个新的和改进的安全性和可持续性设计评估框架，该框架基于创新的、项目内体外验证和计算机方法、新方法方法（NAMs）和数据。已开发的NAMs涵盖了人体主要靶器官和暴露途径。CHIASMA评估框架将基于基于下一代安全评估（NGSA）的迭代多步骤方法，结合化学中心和生物中心方法和NAMs，它将能够预测监管相关趋势和长期安全性，以及绝对生命周期影响分析（LCIA）。在提交给监管机构之前，将论证开发的方法的科学合理性和性能以及可转移性（包括工业环境）。在至少三个化学品/材料组（PFAS，用于能源应用的二维材料和（纳米）农药）中演示SSbD框架，并在现有方法的背景下进行社会经济方面的评估和差距分析。将表示安全和健康参数的新的和改进的方法纳入现有的生命周期和可持续性评估方法和工具，以及纳入相关的适用监管框架（包括SSbD框架）。为行业和公共机构提供可访问的数据，以最终支持SSbD框架及其标准的更广泛实施。CHIASMA项目将持续48个月。它是有组织的相互依赖的工作流程，它将被分解成9个与科学计划一致的工作包，以提供最佳的项目行为和项目目标的实现。

The CHIASMA’s Central Objective is to develop a new and improved Safety and Sustainable by Design Assessment frameworkbased on innovative, in-project validated in vitro and in silico methods New Approach Methodologies (NAMs) and data for the nextgeneration of hazard- & risk assessment of chemicals and materials. The developed NAMs cover main human target organs and exposureroutes. The CHIASMA Assessment Framework will be based on an iterative multi-step approach based on Next Genaration SafetyAssessment (NGSA) that combines chemocentric and biocentric approaches and NAMs and it will be able to predict regulatory relevantendpoints and long-term safety, together with absolute Life Cycle Impact Analysis (LCIA). Developed methods will be demonstratedfor scienfic soundness and performances and for transferability (including to industrial environment), prior to submission to regulatorybodies. Demonstration of the SSbD Framework in at least three chemicals/materials groups (PFAS, 2D materials for energy applicationsand (nano-)pesticides), supported by the assessment of socio-economic aspects and gap analyses in the context of existing methods.Integration of the new & improved methods for expressing safety and health parameter into existing life-cycle and sustainabilityassessments methodologies and tools, as well as into the relevant applicable regulatory frameworks (incl. the SSbD framework). Provisionof accessible data for industry and public authorities, in order to ultimately support the wider implementation of the SSbD frameworkand its criteria. The CHIASMA Project will run for 48 months. It is organised interdependent workflows, which will be broken downinto 9 workpackages aligned with the scientific plan in order provide an optimum project-conduct and achievement of Project objectives.