IMPLEMENTING INNOVATIVE METHODS FOR SAFETY AND SUSTAINABILITY ASSESSMENTS OF CHEMICALS AND MATERIALS PARTICULARLY AT NANO LEVEL IN THE EUROPEAN UNION

在欧盟实施化学品和材料安全性和可持续性评估的创新方法，特别是纳米级的评估

• 批准号: 10109804
• 金额: $ 49.72万
• 依托单位: MANCHESTER METROPOLITAN UNIVERSITY
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10109804
• 关键词: IMPLEMENTING; INNOVATIVE; METHODS; SAFETY; SUSTAINABILITY

The Chemicals Strategy for Sustainability (CSS) has been adopted, which aims to tackle the challenge of producing and using chemicals to address societal needs while respecting the planetary boundaries and safeguarding people and ecosystems, by dealing with pollution from all sources (EC, 2019 or COM(2019)640final, COM(2020)667 final, JRC report). This CSS challenge gets operationalised through the development/implementation of two key R&I actions: 1) the Strategic Research and Innovation Plan (SRIP), and 2) the Safe and Sustainable by Design (SSbD) framework. Consistent with the aims of the Call HORIZON-CL4-2023- RESILIENCE-01-21 and bearing in the mind the pressing need to develop new methods or improve current ones, to support the improvement of safety and sustainability assessments of chemicals, the project “IMPLEMENTING INNOVATIVE METHODS FOR SAFETY AND SUSTAINABILITY ASSESSMENTS OF CHEMICALS AND MATERIALS PARTICULARLY AT NANO LEVEL IN THE EUROPEAN UNION (CheMatSustain)” will not only study the quantum effects from a fundamental point-of-view (by DFT means) but also by identifying and measuring them through experimental techniques (high-resolution analysis, XPS and UPS), and determining the specific molecular recognition through their interaction with the environment, which is a quantum mechanical effect (in vitro, microfluidic in-vitro, and in-vivo models and proteomics and transcriptomics and methods). The obtained information on these descriptors will then be integrated for the development of novel in silico models for prediction (eco)toxicity properties of advanced materials. Finally, in-silico model prediction results will be combined to develop a new methodology for the complementary use of Risk Assessment and LCA to improve criteria for the SSbD implementation framework. The work has been divided in eight work packages and the duration of the project is 48 months.

化学品可持续发展战略（CSS）旨在应对生产和使用化学品的挑战，以满足社会需求，同时尊重地球边界，保护人类和生态系统，通过处理所有来源的污染（EC，2019或COM（2019）640最终版，COM（2020）667最终版，JRC报告）。这一CSS挑战通过制定/实施两项关键的R&I行动来实现：1）战略研究和创新计划（SRIP），以及2）安全和可持续设计（SSbD）框架。根据呼吁HORIZON-CL 4 -2023- RESILIENCE-01-21的目标，并铭记迫切需要开发新方法或改进现有方法，以支持改进化学品的安全和可持续性评估，欧洲联盟“特别是在纳米一级实施化学品和材料安全和可持续性评估创新方法”项目（CheMatSustain）”将不仅从基本的角度研究量子效应，（通过DFT手段），但也通过识别和测量它们通过实验技术（高分辨率分析，XPS和UPS），并通过它们与环境的相互作用确定特定的分子识别，这是一种量子力学效应（体外、微流体体外和体内模型以及蛋白质组学和转录组学和方法）。这些描述符上获得的信息，然后将被整合为新的预测（生态）先进材料的毒性性能的计算机模型的发展。最后，将结合计算机模拟模型预测结果，开发一种新的方法，用于风险评估和LCA的互补使用，以改进SSbD实施框架的标准。这项工作分为八个工作包，项目期限为48个月。