Research Project 2 - Internal state dynamics of primate perception and decision-making

研究项目2 -灵长类动物感知和决策的内部状态动力学 负责人：Eyal Seidemann博士 项目摘要 RP 2的首要目标是了解灵长类初级视觉皮层（V1）中的神经回路如何相互作用 与其他大脑区域的联系，以提高在要求视觉辨别任务中的行为表现。我们 我将开发和使用一系列前所未有的实验工具，同时进行阅读和写 行为猕猴皮层在多个空间尺度上的神经群体反应。我们的最终目标是发展 并测试定量和机械计算模型，可以解释（1）编码的外部 输入（视觉或光遗传学）的动态V1群体反应，（2）解码V1响应外部 刺激的神经群体在关键下游决策/运动区，调解行为，和（3） 与波动的内部状态相关的V1活动的自发变化之间的相互作用， 影响刺激编码和解码。总之，我们的实验和计算工作将提供 新的见解调解复杂的机制，自然主义，感知引导行为， NHP大脑。

Research Project 2 - Internal state dynamics of primate perception and decision-making Lead: Eyal Seidemann PhD Project Summary The overarching goal of RP2 is to understand how neural circuits in primate primary visual cortex (V1) interact with other brain regions to give rise to behavioral performance in demanding visual discrimination tasks. We will develop and use an unprecedented array of experimental tools for simultaneously reading and writing neural population responses at multiple spatial scales in behaving macaque cortex. Our end goal is to develop and test quantitative and mechanistic computational models that can account for (1) the encoding of external inputs (visual or optogenetic) by dynamic V1 population responses, (2) the decoding of V1 responses to external stimuli by neural populations in key downstream decision/motor areas that mediate behavior, and (3) the interplay between spontaneous variations in V1 activity that are related to fluctuating internal states and their impact on stimulus encoding and decoding. Together, our experimental and computational work will provide novel insights into the mechanisms that mediate complex, naturalistic, perceptually guided behaviors in the NHP brain.