Personalised Adaptive Medicine

个性化药物配方是一个热门话题，但最先进的方法受到低可伸缩性、成本和监管障碍的限制，而目前的聚吡啶配方努力受到液体形式或热熔体添加方法的阻碍，带来了稳定性问题。这些瓶颈带来了巨大的社会代价，因为最近证明，药物组合的协同促进作用显著改善了治疗结果，同时将活性物质保持在理想的生理浓度窗口被认为可以最大限度地提高效率并减少副作用。此外，多药联用是一个真正的问题，导致给药错误和患者依从性的重大损失。最后，尽管遥远地平线上的大数据健康IT系统概念有可能收集基于证据的个性化医疗所需的大量可靠剂量-患者数据，但缺乏提供此类数据的技术-通过双向数字信息流良好跟踪患者/剂量程序。PERAMEDIC项目提出了一个突破性的解决方案来解决这些问题：一个用于个性化药物的独立药物配方系统，提供本地准备的、单独定制的、具有固有数字技术接口的分段释放多聚制剂。该系统依赖于集成几项新技术：个人释放概况，使用自适应刀具路径原位3D打印释放矩阵，以及超精确的多通道粉末给药到密封的微格中。设想的设备将是一台台式大小的药丸/胶囊印刷机，使用粉末状药物和可生物吸收的聚合物基质材料罐。应用场景将首先是临床环境，然后是后期的药房地点和医疗实践，如全科医生办公室。PERAMEDIC将提供功能组合的新技术的实验室规模的概念验证原型系统，并对未来技术进行预览设计。

Personalised drug formulation is a hot topic butstate of the art approaches are limited by low scalability, cost, and regulatory hurdles, while current polypill formulation efforts are hindered by liquid form or hot melt addition approaches, posing stability issues. These bottlenecks carry a great societal price, as the synergic boost of drug combinations was recently demonstrated to reach significant improvement in treatment outcomes, while keeping active substances in the ideal physiological concentration window is known to maximise efficiency and reduce side effects. Also, polypharmacy is a real problem leading to dosing errors and significant loss in patient adherence. Finally, while Big Data Health IT system concepts on the far horizon hold potential to gather the large amount of reliable dosage-patient data required for evidence-based personalised medicine, the technology to deliver such data – well-tracked patient/dosing procedures with bi-directional digital information flow – is missing. The PERAMEDIC project proposes to resolve these problems with a breakthrough solution: a stand-alone drug formulation system for personalised medicine, offering locally prepared, individually customised,segmented release polypills, with an inherently digital technology interface. The system relies on integrating several novel technologies: personal release profiles, in situ 3D printing of release matrix using adaptive toolpaths, and ultra-precise multichannel powder dosing of drugs into sealed microcompartments. The envisaged device would be a desktop-size pill/capsule printing machine, using canisters of powdered drugs and bioresorbable polymer matrix material. Application scenarios would be first clinical settings, then at later stage, pharmacy locations and medical practices such as GP’s office. PERAMEDIC will deliver a lab-scale proof-of-concept prototype system of the functionally combined novel technologies, with a preview design of the future technology.