Admin-Core-001

行政核心项目摘要我们建议建立亚利桑那州癌症和进化中心(ACE)。亚利桑那州立大学将领导亚利桑那州癌症和进化中心的工作。共同首席研究员马利博士和柴田博士将与NCI项目工作人员合作指导该中心。ACE整合了一个由模型师、进化生物学家和癌症生物学家组成的团队，他们有着成功的合作记录。亚利桑那州癌症和进化中心行政核心的目标是为中心的整体组织和有效管理提供必要的基础设施，以实现CSBC和NCI的目标，以及实现中心的科学目标。在这一资助期间，ACE行政核心将实现四个具体目标：目标1创建和保持一支与研究和更广泛的网络相连的知识、技能和跨学科的领导团队；目标2设计和实施整个中心清晰有效的沟通计划；目标3确定和促进试点项目；目标4就ACE的科学方向和机会征求、协调和回应外部建议。影响：管理核心将使亚利桑那州癌症和进化中心通过开发适用于所有癌症和物种的癌症理论、模型和测量方法，改变目前对癌症的理解和管理。

Admin Core Project Summary We propose to establish the Arizona Cancer and Evolution Center (ACE). Arizona State University will lead the Arizona Cancer and Evolution Center effort. Drs. Maley and Shibata, co-principal investigators, will direct the Center in collaboration with NCI program staff. ACE integrates a team of modelers, evolutionary biologists and cancer biologists with a successful track-record of collaborations. The objective of the Arizona Cancer and Evolution Center Administrative Core is to provide the necessary infrastructure for the overall organization and effective management of the Center to achieve the objectives of the CSBC and the NCI, as well as realize the scientific goals of the Center. The ACE Administrative Core will accomplish four Specific Aims during this funding period: Aim 1 Create and maintain a knowledgeable, skilled, and interdisciplinary leadership team that is connected to the research and the wider network; Aim 2 Design and implement a clear and effective communication plan across the Center; Aim 3 Identify and foster pilot projects; Aim 4 Solicit, coordinate, and respond to external advice for the scientific direction and opportunities for ACE. IMPACT: The Administrative Core will enable the Arizona Cancer and Evolution Center to transform current understanding and management of cancer by developing the theory, models, and measures of cancer that will be applicable and clinically relevant across cancers and species.