Admin Core

管理核心项目摘要 我们建议建立亚利桑那州癌症和进化中心（ACE）。亚利桑那州立大学将领导 亚利桑那州癌症和进化中心的努力。共同主要研究者Maley和柴田博士将指导 中心与NCI计划工作人员合作。ACE整合了一个由建模者、进化生物学家和 有着成功合作记录的癌症生物学家。亚利桑那癌症的目标和 演进中心管理核心是为整个组织提供必要的基础设施， 中心的有效管理，以实现CSBC和NCI的目标，以及实现 中心的科学目标。在此期间，ACE行政核心将实现四个具体目标 资助期限：目标1创建和维护一支知识渊博、技能娴熟、跨学科的领导团队， 与研究和更广泛的网络相连;目标2设计和实施一个清晰有效的 目标3确定和促进试点项目;目标4征求、协调和 回应外部建议，为ACE提供科学方向和机会。影响：行政 核心将使亚利桑那州癌症和进化中心能够改变目前的理解， 通过发展适用于癌症的理论，模型和措施来管理癌症， 与癌症和物种的临床相关性。

Admin Core Project Summary We propose to establish the Arizona Cancer and Evolution Center (ACE). Arizona State University will lead the Arizona Cancer and Evolution Center effort. Drs. Maley and Shibata, co-principal investigators, will direct the Center in collaboration with NCI program staff. ACE integrates a team of modelers, evolutionary biologists and cancer biologists with a successful track-record of collaborations. The objective of the Arizona Cancer and Evolution Center Administrative Core is to provide the necessary infrastructure for the overall organization and effective management of the Center to achieve the objectives of the CSBC and the NCI, as well as realize the scientific goals of the Center. The ACE Administrative Core will accomplish four Specific Aims during this funding period: Aim 1 Create and maintain a knowledgeable, skilled, and interdisciplinary leadership team that is connected to the research and the wider network; Aim 2 Design and implement a clear and effective communication plan across the Center; Aim 3 Identify and foster pilot projects; Aim 4 Solicit, coordinate, and respond to external advice for the scientific direction and opportunities for ACE. IMPACT: The Administrative Core will enable the Arizona Cancer and Evolution Center to transform current understanding and management of cancer by developing the theory, models, and measures of cancer that will be applicable and clinically relevant across cancers and species.