Admin-Core-001

行政和临床服务（ACS）中心主任将由Susan Chang博士担任，副主任将由Jennifer Clarke博士担任。行政部门将由Dr. Chang领导，临床部门将由Dr. Clarke领导。Sarah纳尔逊博士和丹尼尔Vigneron博士将担任共同研究者，以监督计划项目的技术方面。Dr. Chang是神经肿瘤科主任，是PI的总体PI，也是之前PPG的行政核心主任。她在协调多个项目和核心方面经验丰富，有效地领导了上一个周期的成功活动。她已明确承诺对方案规划补助金进行监督。ACS核心的具体目标是为我们的所有项目提供行政和临床服务，以实现其特定目标和研究计划。行政支助将包括财政、赠款管理和文书支助，以编写年度进展报告和手稿，组织项目关键人员与核心人员之间的会议，以及与外部咨询委员会的会议。其中两个项目将涉及病人研究，临床部分将提供基础设施和人员，以便进行非治疗和治疗研究。这将包括临床科学家、神经外科医生、研究护士和临床研究助理，以及获得知情同意、治疗和随访所有项目临床研究中入组患者的临床空间。ACS核心的总体目标是促进P01成员之间的互动，为项目提供临床研究支持，并在行政上协调P01研究者的活动。下表描述了ACS核心的两个组成部分向四个项目提供的工作分配。组成项目1项目2项目3项目4总计行政25% 25% 25% 25% 100%临床60% 0% 0% 40% 100%

The Director of the Administrative and Clinical Services (ACS) Core will be Dr. Susan Chang and the Associate Director will be Dr. Jennifer Clarke. The Administrative component will be led by Dr. Chang and the Clinical component will be led by Dr. Clarke. Dr. Sarah Nelson and Dr. Daniel Vigneron will serve as co-investigators in order to provide oversight of the technical aspects of the Projects planned. Dr. Chang is the Director of the Division of Neuro-Oncology and is the overall PI of the PI and was as well as the director of the Administrative Core of the prior PPG. She is experienced in the coordination of multiple projects and cores and has effectively provided the leadership for the successful activities of the previous cycle. She has demonstrated clear commitment to providing oversight of the PPG. The specific aims of the ACS Core are to provide Administrative and Clinical services to all our Projects to accomplish their Specific Aims and Research Plans. Administrative support will include fiscal, grants management and clerical support for annual progress reports and manuscript preparation, and organization for meetings between the key personnel from the projects and cores, as well as for meetings with the External Advisory Board. Two of the Projects will involve patient research studies and the clinical component will provide the infrastructure and personnel to allow the conduct of non-therapeutic and therapeutic research studies. This will include clinical scientists, neurosurgeons, research nurses and clinical research assistants, as well as clinical space to obtain informed consent, treat, and follow patients enrolled in clinical studies within all the Projects. The overall goal of the ACS Core will be to facilitate the interactions of the members of this P01, provide clinical research support for the Projects, and administratively coordinate activities of the P01investigators. The following table depicts the distribution of effort provided to the four Projects by the two components of the ACS Core. Component Project 1 Project 2 Project 3 Project 4 Total Administrative 25% 25% 25% 25% 100% Clinical 60% 0% 0% 40% 100%