Molecular basis of nucleotide signalling by TIR domain containing proteins

依赖于烟酰胺腺嘌呤二核苷酸(NAD+)的信号通路在神经退行性疾病和细菌防御系统中发挥着重要作用，因此是开发新的治疗方法和生物技术工具的潜在靶点。这个项目旨在增加我们对一类新的酶的生物学的理解，这些酶参与了生命领域中的NAD+信号传递。该项目预计将揭开基于核苷酸的信号传递的一般原理，预期的结果将包括与哺乳动物和细菌系统中的细胞死亡和病原体防御相关的新的分子机制，这将为人类生物学和生物技术的一系列应用提供重大好处。

Nicotinamide adenine dinucleotide (NAD+) dependent signalling pathways play important roles in neurodegenerative diseases and bacterial defence systems, and are therefore potential targets for the development of new therapeutics and biotechnology tools. This project aims to increase our understanding of the biology of a novel class of enzymes involved in NAD+ signalling across the domains of life. The project is expected to unravel general principles of nucleotide-based signalling, and the expected outcomes will include new molecular mechanisms relevant to cell-death and pathogen defence in mammalian and bacterial systems, which should provide significant benefit for a range of applications in human biology and biotechnology.