Neural Mechanisms of Monoaminergic Engagement in Late-Life Depression Treatment Response (NEMO)

摘要 R 01 MH 076079晚年抑郁症治疗中单胺能参与的神经机制 响应[NEMO]测试描述核心治疗相关动态变化的机制模型 认知和情感网络（CAN）在休息和标准的行为任务，以及调节 血管负荷对CAN接合和治疗反应之间的关联的作用。我们建议 招募了100名老年抑郁症患者。该奖项于2017年1月1日获得。从那时起，我们就 所有调整后的招聘里程碑，直到第四年，当由于COVID大流行，我们不得不停止 招募，因为我们的潜在参与者处于高风险年龄组（60岁及以上）。截至2021年6月， 我们已经完成了54%的招募计划我们预计到2021年12月（奖励结束），我们将招募一名 共有64名参与者。为了能够在研究的两个目标中为分析提供动力，我们需要招募 至少80个主题。因此，我们需要在要求增加的5个研究对象中增加16个 几个月的资金。这一明智的目标是根据2000年前四年的征聘速度确定的。 项目这对于成功分析数据至关重要（基于功效计算）。当我们到达终点时， 在这项研究的资助期内，我们计划提交一份竞争性的延续报告， 从目前的提案中获得了有力的结果。所要求的资金专门用于收回已支付的薪金 在关机期间。本建议书响应NOT-MH-21-120，因为1）它在 资助的研究; 2）NEMO是在该奖项的最后一年; 3）完成招生， 后续行动对当前项目的成功至关重要。

ABSTRACT R01 MH076079 Neural Mechanisms of Monoaminergic Engagement in Late-Life Depression Treatment Response [NEMO] tests a mechanistic model that describes the treatment-related dynamic changes of the core cognitive and affective networks (CAN) at rest and during standard behavioral tasks as well as the moderating role of vascular burden on the association between CAN engagement and treatment response. We proposed to recruit 100 older adults with late-life depression. The award was received on January 1, 2017. Since then, we hit all the adjusted recruitment milestones until year 4, when due to the COVID pandemic we had to halt recruitment as our potential participants were in the higher-risk age group (60 and older). As of June 2021, we are at 54% of projected recruitment. We project that by December 2021 (end of award), we will recruit a total of 64 participants. In order to be able to power the analyzes in both aims of the study we need to recruit at least 80 subjects. Thus, we need to recruit an additional 16 subjects during the requested additional five months of funding. This judicious target is based on the pace of recruitment during the first four years of the project. This is crucial for the successful analysis of data (based on power calculations). As we reach the end of the funding period for this study, we are planning to submit a competing continuation that would rely on the powered results from the current proposal. The requested funds are specifically aimed to recover salaries paid during shutdown. This proposal is responsive to NOT-MH-21-120 as 1) it is within the scope of the funded research; 2) NEMO is in the last year of the award; 3) completion of enrollment and follow-up are critical for the success of the current project.