UAB Nutrition Obesity Research Center (NORC)

UAB NORC计划摘要/摘要 我们要求提供资金以继续和扩大UAB的营养性肥胖所取得的显著成功 研究中心(NORC)在其前四个资助周期中，特别是在过去四年多的时间里。就职典礼 在2000年NIH的资助下，我们的NORC促进了多学科、协作性、基础性、临床和转化性 营养与肥胖的研究。北大西洋公约组织的研究基础在数量和生产力上逐渐增长 经历了前三个资金周期，但在最后一个资金周期中实现了资金的爆炸性增长 句号。UAB NORC支持一个由95名正式成员(63名成员)和11名初级成员组成的研究基地 会员。成长来自1)初级研究人员的成功；2)吸引其他UAB研究人员进入 研究基地；3)招募新的研究人员。我们的研究基地产生了超过4100万美元的收入(上升 从2100万美元)直接资助营养/肥胖研究，并发表了438篇同行评议论文 过去的资助期。在1)肥胖和代谢失调方面做出了重要贡献；2) 减肥和减肥保持：3)精确的营养和肥胖方法；4)减少肥胖 5)残障人士的营养、运动、肥胖。更令人印象深刻的是 NORC在促进跨学科合作方面的成功，这些合作导致了大笔赠款的成功(P 和U奖)。特别是，一项慢性病中心的申请(P50)刚刚获得资金， 申请精准营养临床中心(UO1)收到了可能成功的优先分数 从2021年底开始提供资金。这两笔大笔赠款都广泛使用了NORC的核心。我们的NORC 支持三个常用的核心实验室--新陈代谢、动物模型、行为科学和分析。 前两个核心功能完善，第三个核心已从可添加服务的生物统计核心发展而来 协助不同的研究设计、复杂的数据分析和行为科学。我们NORC的领导层 负责监督三项由美国国立卫生研究院资助的肥胖研究T32培训补助金。我们的NORC资助了一个成功的试点& 可行性计划，并赞助了一名指定的新调查员。我们的浓缩项目一直很出色 邀请顶尖科学家参加我们的系列研讨会，并促进研究合作。UAB已承诺 在未来5年内向NORC提供超过500万美元的资金。有卓越的机构支持和学术支持 在基础设施方面，我们请求提供新的资金，以继续为这一重要的研究领域作出贡献。

UAB NORC PROGRAM SUMMARY/ABSTRACT We request funding to continue and expand on the outstanding success achieved by UAB's Nutrition Obesity Research Center (NORC) in its first four funding cycles and particularly during the past 4+ years. Inaugurated with NIH funding in 2000, our NORC fosters multidisciplinary, collaborative, basic, clinical, and translational research in nutrition and obesity. The NORC's research base grew gradually in number and productivity through the first three funding cycles but has achieved explosive growth in funding during the last funding period. The UAB NORC supports a research base of 95 regular members (up from 63 members) and 11 junior members. Growth came from 1) success of junior researchers; 2) attraction of other UAB researchers into the research base; and 3) recruitment of new researchers. Our research base generates over $41,000,000 (up from $21,000,000) in direct funding for nutrition/obesity research and published 438 peer-reviewed papers over the past funding period. Important contributions were made in 1) obesity and metabolic dysregulation; 2) weight loss and weight loss maintenance: 3) precision approaches to nutrition and obesity; 4) reducing obesity in the community; 5) nutrition, exercise, obesity in individuals with disabilities. Even more impressive has been success of the NORC in facilitating interdisciplinary collaborations that have led to success with large grants (P and U awards). In particular, an application for a Chronic Disease Center (P50) was just funded and an application for a Precision Nutrition Clinical Center (UO1) received a priority score that is likely to be successful in funding beginning in late 2021. Both of these large grants extensively use the NORC cores. Our NORC supports three well-used core laboratories – Metabolism, Animal Models, Behavioral Science and Analytics. The first two cores are well-established, and the third core has evolved from a biostats core to add services to assist with different research designs, complex data analysis and behavioral science. Our NORC leadership oversees three NIH-funded T32 training grants for obesity research. Our NORC funds a successful Pilot & Feasibility program and sponsors a Named New Investigator. Our Enrichment Program has been outstanding in bringing top scientists to our seminar series and in facilitating research collaborations. UAB has committed over $5,000,000 to the NORC over the next 5 years. Backed by exceptional institutional support and academic infrastructure, we request renewed funding to continue our contributions to this important area of research.