An Ecosystem of Technology and Protocols for Adaptive Neuromodulation Research in Humans

项目摘要/摘要 神经和精神障碍影响着美国和世界各地数百万人，并产生 占所有医疗保健费用的三分之一。最近的研究已经产生了令人鼓舞的证据，即适应性神经调节 可以诱导神经系统的可塑性，从而在某些神经疾病中产生长期的改善 例如中风。与此同时，越来越明显的是，支持这些的技术 演示仍然严重不足，研究和临床应用都无法获得：目前 非侵入性技术通常是不精确的；而目前更精确的侵入性技术是 目前只有在严格限制人类使用的情况下才能使用。此外，现存的为数不多的神经调节 人类使用的平台需要在工程、生理和监管的不同领域拥有丰富的专业知识 大多数组不可用的域。由于缺乏可用的suffi，因此功能强大且易于使用 神经调节技术极大地阻碍了新的适应性技术的开发、应用和优化 改善破坏性神经和精神疾病症状的方案。 这里提出的项目的目的是通过开发、验证和广泛地 与社区共享易于使用的适应性神经调节生态系统(由技术和 协议)，这是针对侵入性基础和临床研究的需要而优化的。我们将在以下方面验证该生态系统 犬类模型，并将其与适当的文档一起通过三个月传播给其他科学家和临床医生 与项目相关的考点和三个讲习班。为配合这个目标，我们会： 1.开发用于侵入性神经调节研究的通用软硬件神经调节平台 2.建立和验证适应性神经调节研究和临床应用的生态系统 3.传播技术和协议的生态系统 实现这三个目标将创建、验证和传播fi第一个全面的生态系统 促进侵入性适应性神经调节方案的概念、开发和临床应用。 我们预计，这个生态系统的可用性将极大地增加基础和临床神经调节的活动。 研究将导致对正常和异常功能和意志的神经基础的新理解 从而加速开发新的自适应神经调节方案，以改善对许多疾病的治疗 毁灭性的神经紊乱。

Project Summary/Abstract Neurological and psychiatric disorders affect millions of people in the United States and worldwide, and produce a third of all health care costs. Recent research has produced encouraging evidence that adaptive neuromodulation can induce nervous system plasticity that produces long-lasting improvements in certain neurological disorders such as stroke. At the same time, it is becoming increasingly clear that the technologies that support these demonstrations remain painfully inadequate and inaccessible for both research and clinical application: current non-invasive technologies are typically imprecise; and current invasive technologies, which are more precise, are currently only available with serious restrictions for human use. Moreover, all of the few existing neuromodulation platforms for human use require substantial expertise in diverse areas of engineering, physiology, and regulatory domains that is not available to most groups. This lack of availability of sufficiently capable and readily useable neuromodulation technologies greatly impedes the development, application, and optimization of new adaptive protocols for improving symptoms of devastating neurological and psychiatric disorders. The purpose of the project proposed here is to address this critical issue by developing, validating, and widely sharing with the community an easy-to-use adaptive neuromodulation ecosystem (comprised of technology and protocols) that is optimized for the needs of invasive basic and clinical research. We will validate this ecosystem in a canine model, and disseminate it with appropriate documentation to other scientists and clinicians through three project-related test sites and three workshops. In accord with this objective, we will: 1. Develop a general-purpose hardware/software neuromodulation platform for invasive neuromodulation research 2. Develop and validate an ecosystem for adaptive neuromodulation research and clinical application 3. Disseminate this ecosystem of technologies and protocols Achieving these three aims will create, validate, and disseminate the first comprehensive ecosystem that facilitates the conception, development, and clinical application of invasive adaptive neuromodulation protocols. We expect that the availability of this ecosystem will greatly increase activities in basic and clinical neuromodulation research that will lead to new understanding of the neural underpinnings of normal and abnormal function and will thereby accelerate the development of novel adaptive neuromodulation protocols to improve treatment for many devastating neurological disorders.