权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

An Ecosystem of Technology and Protocols for Adaptive Neuromodulation Research in Humans

人类自适应神经调节研究的技术和协议生态系统

基本信息

批准号：
10707462
负责人：
Peter Brunner
金额：
$ 133.08万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-21 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10707462
关键词：
Acceleration Achievement Address Adoption Affect Animals Area Basic Science Behavioral Brain Cardiovascular Diseases Clinical Clinical Protocols Clinical Research Collaborations Communication Communities Computer software Conceptions Data Dedications Democracy Development Devices Diabetes Mellitus Diagnosis Disabled Persons Documentation Ecosystem Educational workshop Engineering Feedback Goals Health Care Costs Human Implant Malignant Neoplasms Mental Depression Mental disorders Movement Disorders Mus Nervous System Operative Surgical Procedures Pain Performance Persons Physiology Protocols documentation Research Resistance Scientist Signal Transduction Site Spinal cord injury Stroke Structure Support System System Technology Testing Time Training United States Work brain based canine model clinical application communication aid experimental study implantation improved nervous system disorder neural neuroregulation neurotechnology nonhuman primate novel novel therapeutics open source research clinical testing success symptomatic improvement theories verification and validation

项目摘要

Project Summary/Abstract Neurological and psychiatric disorders affect millions of people in the United States and worldwide, and produce a third of all health care costs. Recent research has produced encouraging evidence that adaptive neuromodulation can induce nervous system plasticity that produces long-lasting improvements in certain neurological disorders such as stroke. At the same time, it is becoming increasingly clear that the technologies that support these demonstrations remain painfully inadequate and inaccessible for both research and clinical application: current non-invasive technologies are typically imprecise; and current invasive technologies, which are more precise, are currently only available with serious restrictions for human use. Moreover, all of the few existing neuromodulation platforms for human use require substantial expertise in diverse areas of engineering, physiology, and regulatory domains that is not available to most groups. This lack of availability of sufﬁciently capable and readily useable neuromodulation technologies greatly impedes the development, application, and optimization of new adaptive protocols for improving symptoms of devastating neurological and psychiatric disorders. The purpose of the project proposed here is to address this critical issue by developing, validating, and widely sharing with the community an easy-to-use adaptive neuromodulation ecosystem (comprised of technology and protocols) that is optimized for the needs of invasive basic and clinical research. We will validate this ecosystem in a canine model, and disseminate it with appropriate documentation to other scientists and clinicians through three project-related test sites and three workshops. In accord with this objective, we will: 1. Develop a general-purpose hardware/software neuromodulation platform for invasive neuromodulation research 2. Develop and validate an ecosystem for adaptive neuromodulation research and clinical application 3. Disseminate this ecosystem of technologies and protocols Achieving these three aims will create, validate, and disseminate the ﬁrst comprehensive ecosystem that facilitates the conception, development, and clinical application of invasive adaptive neuromodulation protocols. We expect that the availability of this ecosystem will greatly increase activities in basic and clinical neuromodulation research that will lead to new understanding of the neural underpinnings of normal and abnormal function and will thereby accelerate the development of novel adaptive neuromodulation protocols to improve treatment for many devastating neurological disorders.

项目总结/文摘