Administrative Core

摘要 我们的腺瘤翻译和基础科学中心(TBAC)的行政核心将服务于 优化和整合项目实验室与对方项目实验室的研究流程 带着核心。行政核心将提供后勤支持、加强沟通、便利数据 传播和建立一个由私人投资机构对项目进行结构化监督的制度。行政核心 还将提供行政支持，以促进其他技术支持机构之间的协作和沟通 协调和数据管理中心(CDMC)；NCI工作人员，协作工业和 学术合作伙伴和合作的NCI项目(例如，CISNET、NIST等)。行政核心意志 提供指导并加强TBAC、TBEL社区成员和TBAC之间的沟通 外部合作伙伴。 TBAC由项目实验室的三个调查小组组成：项目1(Grady，Yu，Maroni- 拉纳、戴、卡特)、项目2(哈尔伯格、斯宾格勒、斯诺、牛顿)和项目3(戴伊、莫雷拉、拉钱斯)以及 翻译病理学和数据分析核心(Matkowsky，Pickhardt，Sun，Kendziorski，Dinh)，谁将 通过行政核心的协调，作为一个无缝的单位发挥作用。TBAC将密切互动 与其他TBEL中心和CDMC的核心任务是阐明翻译和早期生物学 腺瘤。TBAC还将根据需要与行业合作伙伴和学术合作伙伴进行合作，以 推进项目研究。TBAC、其他TBEL中心、TBEL CDMC、行业合作伙伴和学术界 合作伙伴将就本提案中的研究以及由此产生的任何衍生研究进行合作 来自TBAC的高度创新、富有成效和重要意义的基本和 腺瘤的翻译生物学。 行政核心有以下具体目的/目标： 具体目标1：为支持全面预算咨询委员会的主要目标提供组织结构 具体目标2：提高管理大规模协作研究工作的效率，包括 多个机构和多个PD/PI 具体目标3：与TBELCDMC和TBEL社区议定书的制定协调， 生物样本共享、生物样本盲化、数据分析、数据共享、数据协调、数据存储、 填充任何数据共享空间，以及任何其他被认为是TBAC操作所必需的相关功能 至于更大的tbel社区。

SUMMARY The Administrative Core of our Translational and Basic Science of Adenomas Center (TBAC) will serve to optimize and integrate the investigative processes of the Project Labs between each other and the Project Labs with the Cores. The Administrative Core will provide logistical support, enhance communication, facilitate data dissemination and create a system for structured oversight of the projects by the PIs. The Administrative Core will also provide administrative support to facilitate collaborations and communications between the other TBEL Centers, the Coordinating and Data Management Center (CDMC); NCI staff, collaborating industrial and academic partners, and collaborating NCI programs (e.g. CISNET, NIST, etc.). The Administrative Core will provide guidance and enhance communication for and between the TBAC, TBEL Community members and external partners. The TBAC is comprised of three teams of investigators in the Project Labs: Project 1 (Grady, Yu, Maroni- Rana, Dai, Carter), Project 2 (Halberg, Spengler, Snow, Newton), and Project 3 (Dey, Morella, LaChance) and the Translational Pathology and Data Analysis Core (Matkowskyj, Pickhardt, Sun, Kendziorski, Dinh), who will function as a seamless unit though the coordination of the Administrative Core. The TBAC will interact closely with other TBEL Centers and the CDMC in its core mission to elucidate the translational and early biology of adenomas. The TBAC will also have collaborations with industrial partners and academic partners as needed to advance the Projects’ studies. The TBAC, other TBEL Centers, TBEL CDMC, industrial partners, and academic partners will collaborate on the studies in this proposal as well as on any resulting derivative studies that arise from the TBAC’s highly innovative, productive and significant program of investigation of the basic and translational biology of adenomas. The Administrative Core has the following Specific Aims/Goals: Specific Aim 1: To provide the organizational structure for supporting the key objectives of the TBAC Specific Aim 2: To provide efficiency in management of large-scale collaborative research efforts involving multiple institutions and multiple PDs/PIs Specific Aim 3: To coordinate with the TBEL CDMC and the TBEL community protocol development, biospecimen sharing, biospecimen blinding, data analysis, data sharing, data harmonization, data deposition, populating any data commons, and any other relevant functions deemed necessary for TBAC operations as well as for the larger TBEL community.